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- W4247470618 abstract "BCX-1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme-catalyzed CN bond cleavage of nucleosides. BCX-1777 is a slow-onset, tight-binding inhibitor with a Ki* of 23 pM and is one of the most potent inhibitors known for the enzyme. In support of our BCX-1777 program, a mass spectrometric assay has been developed utilizing 5′-[2H]-BCX-1777 as an internal standard. The synthesis of 5′-[2H]-BCX-1777 is described in this report. Copyright © 2002 John Wiley & Sons, Ltd." @default.
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- W4247470618 date "2002-01-01" @default.
- W4247470618 modified "2023-09-27" @default.
- W4247470618 title "Synthesis of deuterated-BCX-1777, a potent inhibitor of purine nucleoside phosphorylase" @default.
- W4247470618 doi "https://doi.org/10.1002/jlcr.533.abs" @default.
- W4247470618 hasPublicationYear "2002" @default.
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