FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247483341> ?p ?o ?g. }

• W4247483341 abstract "Abstract Background: As the population ages clinical frailty among older adults admitted to intensive care has been proposed as an important determinant of patient outcomes. Among this group of patients an acute episode of delirium is also common, but its relationship to frailty and increased risk of mortality has not been extensively explored. Therefore, the aim of this study was to explore the relationship between clinical frailty, delirium and hospital mortality of older adults admitted to intensive care. Methods: This study is part of a Delirium in Intensive Care (Deli) study that is being conducted across the SWSLHD between May 1 st 2019 and the end of April 2020. During the initial 6-month baseline period, clinical frailty status on admission to intensive care, among adults aged 50-years or more, acute episodes of delirium, and the outcomes of intensive care and hospital stay will be described. Mediation analysis was used to assess the relationship between frailty and increased risk of hospital death and delirium. Results: During the 6-month baseline period 997 patients, aged 50-years or more, were included in this study. The average age was 71-years (IQR, 63-79), 55% were male (n = 537). Among these patients 39.2% (95% CI 36.1 – 42.3%, n = 396) had a Clinical Frailty Score (CFS) of 5 or more, and 13.0% (n=127) had at least one acute episode of delirium. Frail patients were at greater risk of an episode of delirium (17% versus 10%, adjusted Rate Ratio ( adj RR) = 1.61, 95% Confidence Interval (CI) 1.14 – 2.28, p = 0.007), had a longer hospital stay (2.6 days, 95% CI 1-7 days, p = 0.009), and higher risk of hospital mortality (19% versus 7%, adj RR = 2.43, 95% CI 1.68 – 3.57, p < 0.001), when compared to non-frail patients. Patients who were frail and experienced an acute episode of delirium in the intensive care had a 35% rate of hospital mortality, versus 10% among non-frail patients who also experienced delirium in the ICU ( p = 0.034, for interaction between frailty, delirium and hospital mortality). The proportion of the effect of frailty and risk of hospital mortality mediated by an acute episode of delirium in the ICU was estimated to 9.4% (95% CI 2 – 24%). Conclusion: This study among adults, aged 50-years or more, admitted to intensive care has been able to show that clinical frailty on admission increases the risk of delirium by approximately 60%, and both increase the risk of hospital mortality. One in three frail patients who experienced an acute episode of delirium during their stay in the intensive care did not survive to hospital discharge. These results suggest the importance of recognising clinical frailty in the intensive care setting, not just to improve the prediction of outcomes from critical illness, but to identify patients at the greatest risk of adverse events such as delirium, and institute measures to reduce risk, and, importantly to discuss these issues in an open and empathetic way with the patient and their families." @default.
• W4247483341 created "2022-05-12" @default.
• W4247483341 creator A5000787215 @default.
• W4247483341 creator A5003822713 @default.
• W4247483341 creator A5010213047 @default.
• W4247483341 creator A5022835296 @default.
• W4247483341 creator A5026510696 @default.
• W4247483341 creator A5036412527 @default.
• W4247483341 creator A5038641120 @default.
• W4247483341 creator A5046654659 @default.
• W4247483341 creator A5049539955 @default.
• W4247483341 creator A5055613257 @default.
• W4247483341 creator A5065755762 @default.
• W4247483341 creator A5067072561 @default.
• W4247483341 creator A5068778902 @default.
• W4247483341 creator A5072401570 @default.
• W4247483341 creator A5077797581 @default.
• W4247483341 creator A5078022398 @default.
• W4247483341 creator A5081287109 @default.
• W4247483341 creator A5083627782 @default.
• W4247483341 creator A5084798222 @default.
• W4247483341 date "2020-09-02" @default.
• W4247483341 modified "2023-09-26" @default.
• W4247483341 title "Frailty, delirium and hospital mortality of older adults admitted to intensive care: the Delirium (Deli) in ICU study." @default.
• W4247483341 doi "https://doi.org/10.21203/rs.3.rs-52423/v2" @default.
• W4247483341 hasPublicationYear "2020" @default.
• W4247483341 type Work @default.
• W4247483341 citedByCount "0" @default.
• W4247483341 crossrefType "posted-content" @default.
• W4247483341 hasAuthorship W4247483341A5000787215 @default.
• W4247483341 hasAuthorship W4247483341A5003822713 @default.
• W4247483341 hasAuthorship W4247483341A5010213047 @default.
• W4247483341 hasAuthorship W4247483341A5022835296 @default.
• W4247483341 hasAuthorship W4247483341A5026510696 @default.
• W4247483341 hasAuthorship W4247483341A5036412527 @default.
• W4247483341 hasAuthorship W4247483341A5038641120 @default.
• W4247483341 hasAuthorship W4247483341A5046654659 @default.
• W4247483341 hasAuthorship W4247483341A5049539955 @default.
• W4247483341 hasAuthorship W4247483341A5055613257 @default.
• W4247483341 hasAuthorship W4247483341A5065755762 @default.
• W4247483341 hasAuthorship W4247483341A5067072561 @default.
• W4247483341 hasAuthorship W4247483341A5068778902 @default.
• W4247483341 hasAuthorship W4247483341A5072401570 @default.
• W4247483341 hasAuthorship W4247483341A5077797581 @default.
• W4247483341 hasAuthorship W4247483341A5078022398 @default.
• W4247483341 hasAuthorship W4247483341A5081287109 @default.
• W4247483341 hasAuthorship W4247483341A5083627782 @default.
• W4247483341 hasAuthorship W4247483341A5084798222 @default.
• W4247483341 hasBestOaLocation W42474833411 @default.
• W4247483341 hasConcept C160735492 @default.
• W4247483341 hasConcept C162324750 @default.
• W4247483341 hasConcept C177713679 @default.
• W4247483341 hasConcept C194828623 @default.
• W4247483341 hasConcept C2776376669 @default.
• W4247483341 hasConcept C2779753318 @default.
• W4247483341 hasConcept C2781385661 @default.
• W4247483341 hasConcept C2908647359 @default.
• W4247483341 hasConcept C2987404301 @default.
• W4247483341 hasConcept C50522688 @default.
• W4247483341 hasConcept C71924100 @default.
• W4247483341 hasConcept C99454951 @default.
• W4247483341 hasConceptScore W4247483341C160735492 @default.
• W4247483341 hasConceptScore W4247483341C162324750 @default.
• W4247483341 hasConceptScore W4247483341C177713679 @default.
• W4247483341 hasConceptScore W4247483341C194828623 @default.
• W4247483341 hasConceptScore W4247483341C2776376669 @default.
• W4247483341 hasConceptScore W4247483341C2779753318 @default.
• W4247483341 hasConceptScore W4247483341C2781385661 @default.
• W4247483341 hasConceptScore W4247483341C2908647359 @default.
• W4247483341 hasConceptScore W4247483341C2987404301 @default.
• W4247483341 hasConceptScore W4247483341C50522688 @default.
• W4247483341 hasConceptScore W4247483341C71924100 @default.
• W4247483341 hasConceptScore W4247483341C99454951 @default.
• W4247483341 hasLocation W42474833411 @default.
• W4247483341 hasLocation W42474833412 @default.
• W4247483341 hasLocation W42474833413 @default.
• W4247483341 hasOpenAccess W4247483341 @default.
• W4247483341 hasPrimaryLocation W42474833411 @default.
• W4247483341 hasRelatedWork W11825459 @default.
• W4247483341 hasRelatedWork W1358318 @default.
• W4247483341 hasRelatedWork W14675889 @default.
• W4247483341 hasRelatedWork W15421203 @default.
• W4247483341 hasRelatedWork W16487314 @default.
• W4247483341 hasRelatedWork W16552279 @default.
• W4247483341 hasRelatedWork W16996996 @default.
• W4247483341 hasRelatedWork W20451214 @default.
• W4247483341 hasRelatedWork W581576 @default.
• W4247483341 hasRelatedWork W7375710 @default.
• W4247483341 isParatext "false" @default.
• W4247483341 isRetracted "false" @default.
• W4247483341 workType "article" @default.