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- W4247491256 abstract "Recombination activating gene 1 (RAG-1) is one of the two subunits of the V(D)J recombinase. Along with RAG-2, it is expressed in B and T-cells and is required for recombination of the immunoglobulin (BCR) and T-cell receptor genes. This chapter presents a study in which RAG-l–/– mutant mice appeared healthy and fertile. The mice exhibited greatly reduced cellularity in all primary and secondary lymphoid organs. Analysis of the spleen, bone marrow, and thymus revealed a complete absence of mature B and T lymphocytes, and serum IgM was not detectable. Southern blot analysis of Abelson-transformed cell lines demonstrates that V(D)J recombination was absent. Despite the fact that RAG-1 had been demonstrated to be expressed in the central nervous system, RAG-1-deficient mice did not demonstrate any neuroanatomical or behavioral abnormalities. RAG-1plays a crucial role in the initiation and/or the catalysis of V(D)J recombination in B and T lymphocytes." @default.
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- W4247491256 date "1998-01-01" @default.
- W4247491256 modified "2023-09-27" @default.
- W4247491256 title "RAG-1" @default.
- W4247491256 doi "https://doi.org/10.1016/b978-012466044-1/50494-4" @default.
- W4247491256 hasPublicationYear "1998" @default.
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