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- W4247514241 abstract "In the last few years, there have been significant changes in our understanding of the pathophysiology and approach to treatment of a number of pulmonary disorders. In 1981, heart-lung transplantation was introduced as the first truly viable option for the long-term treatment of pulmonary hypertension secondary to primary pulmonary hypertension and Eisenmenger's syndrome. In the short time since then, breakthroughs in surgical techniques and the availability of cyclosporine have permitted a number of new transplantation techniques, including single-lung, double-lung, and now bilateral sequential lung transplants. Single-lung replacement initially was recommended only for patients with end-stage interstitial lung disease. The transplant procedure improved overall function, and the use of only one lung simplified the surgical technique compared with heart-lung transplantation, lowering the perioperative morbidity and mortality and increasing the number of organs available for transplantation. Initially, it was thought that a single-lung transplant would be inappropriate for patients with associated cor" @default.
- W4247514241 created "2022-05-12" @default.
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- W4247514241 date "1992-07-15" @default.
- W4247514241 modified "2023-09-27" @default.
- W4247514241 title "Pulmonary Medicine" @default.
- W4247514241 doi "https://doi.org/10.1001/jama.1992.03490030117052" @default.
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