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- W4247519076 abstract "Dengue fever/dengue hemorrhagic fever is the most important arboviral disease of humans. In the past 40 years, there has been a dramatic global re-emergence of dengue fever with expanding geographic distribution of both the viruses and the mosquito vectors, resulting in increased frequency and magnitude of epidemic activity and the emergence of a severe form of the disease, dengue hemorrhagic fever. Primarily a tropical urban disease, in 2014, between 3 and 4 billion people live in areas at risk for infection by dengue viruses and annually there are an estimated 400 million infections. Dengue hemorrhagic fever is a leading cause of hospitalization and death among children in many Southeast Asian countries. In addition to the public health impact, dengue places a heavy economic and social burden on endemic countries. It is estimated that the disease costs countries of southeast Asia US$ 1 billion annually, mainly in lost productivity. There are four antigenically related, but distinct dengue virus serotypes (DENV-1, DENV-2, DENV-3, and DENV-4), all of which can cause mild to severe and fatal disease in humans. All four original serotypes have similar natural histories, including an enzootic cycle involving nonhuman primates and canopy dwelling mosquitoes in Asia, and an urban cycle involving humans as the primary vertebrate host and Aedes aegypti mosquitoes of the subgenus Stegomyia as the primary urban mosquito vector globally in the topics. A new virus which is closely related to DENV-4, was isolated in Borneo in 2007. Genetic and antigenic relationships suggest this may be a new serotype (DENV-5), but the data needed to confirm this are pending. These viruses make up the dengue complex within the family Flaviviridae, genus Flavivirus. This article reviews the history, epidemiology, biology, clinical features, pathogenesis, and prevention and control of dengue viruses." @default.
- W4247519076 created "2022-05-12" @default.
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- W4247519076 date "2014-01-01" @default.
- W4247519076 modified "2023-10-02" @default.
- W4247519076 title "Dengue Viruses☆" @default.
- W4247519076 doi "https://doi.org/10.1016/b978-0-12-801238-3.02556-3" @default.
- W4247519076 hasPublicationYear "2014" @default.
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