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- W4247539503 abstract "Mutations in transporters associated with antigen processing (TAP-1 and -2) required for the transport of cytosolic endogenous peptides to the endoplasmic reticulum correlate with increased metastatic potential and reduced host survival in several malignancies. To address the possible function of TAP as a “tumor suppressor” gene, we show that correction of TAP-1 and/or TAP-2 defects in B16 mouse melanoma enhanced the cell surface expression of MHC class I molecules and significantly reduced the rate of subcutaneous tumor growth and pulmonary metastatic burden. Cytotoxic assays confirmed increased sensitivity of TAP-1 and/or TAP-2 transfected clones of B16 melanoma to cytotoxic T lymphocytes. These results indicate that the expression of TAP limits the malignant potential of tumors with implications for CD8+ T cell-based immunotherapy in controlling growth of certain TAP-deficient malignancies." @default.
- W4247539503 created "2022-05-12" @default.
- W4247539503 creator A5005856186 @default.
- W4247539503 date "2004-05-01" @default.
- W4247539503 modified "2023-09-26" @default.
- W4247539503 title "Role of TAP-1 and/or TAP-2 antigen presentation defects in tumorigenicity of mouse melanoma" @default.
- W4247539503 doi "https://doi.org/10.1016/s0008-8749(04)00077-2" @default.
- W4247539503 hasPublicationYear "2004" @default.
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