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- W4247543878 abstract "Problemkind: Bei der Entwicklung und Durchführung eines Hochdurchsatz-Screenings für ein problematisches Zielmolekül, Adenosin-Desaminase (ADA), wurde die DNA-Aptamer-Signaltechnik angewendet. Hierbei wird ein signalgebendes DNA-Aptamer verwendet, das auf die Adenosinkonzentration anspricht. Der Assay erwies sich beim Screening von mehr als 44 000 Molekülen als robust und entdeckte einen neuen kompetitiven Desaminase-Inhibitor. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z601695_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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- W4247543878 date "2006-08-25" @default.
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- W4247543878 title "Small-Molecule Screening Made Simple for a Difficult Target with a Signaling Nucleic Acid Aptamer that Reports on Deaminase Activity" @default.
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