FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247555336> ?p ?o ?g. }

• W4247555336 endingPage "297" @default.
• W4247555336 startingPage "287" @default.
• W4247555336 abstract "Vascular endothelial cells form the inner nonthrombogenic lining of the large blood vessel. Through back-exchange and fluorescence recovery after photobleaching experiments and using the two fluorescent lipids 1 -acyl-2–[6–[N -(7-nitrobenz-2–oxa-1,3–díazol-4-yl)amino]hexanoyl]glycerophosphocholine and 1–acyl-2[6-N -(7-nitrobenz-2–oxa-1,3–díazol-4–yl)amino]hexanoyl]glycerophosphoethanolamine, we have recently shown that an energy-dependent and protein-dependent aminophospholipid translocase activity is present in the plasma membrane of cultured bovine aortic endothelial cells, which specifically transports phosphatidylethanolamine from the outer leaflet toward the inner leaflet of the membrane lipid bilayer. In the present study, using the same approach and 1-acyl-2-[6–N -(7-nitrobenz-2–oxa-1,3-díazol-4-yl)ami-no]hexanoyl]glycerophosphoserine as the probe, it is shown that this conclusion is also valid for phosphatidylserine. Furthermore, evidence is presented indicating that this aminophospholipid translocase activity can be maintained, suppressed, and restored at will, depending on the conditions of cell incubation. Thus, the translocase activity is detected for cells maintained in their normal culture medium or in a serum-free incubation medium [Dulbecco's modified Eagle's medium (DMEM)] supplemented with the basic fibroblast growth factor, whereas inhibition is observed for cells exposed for at least 2 h to DMEM. The translocase activity is restored when these pretreated cells are further incubated at least for 1 h in the presence of serum or of basic fibroblast growth factor. In view of the importance of basic fibroblast growth factor as a mitogenic and differentiating agent for vascular endothelial cells, various growth factors were tested (acidic fibroblast growth factor, epidermal growth factor, platelet-derived growth factor, transforming growth factors α and β, vascular endothelial growth factor, interferon γ, tumor-necrosis factor, insulin, and interleukin 4). Only basic fibroblast growth factor was active in the maintenance and restoration of the translocase activity. With respect to the effects of serum, evidence is presented showing that high-density lipoproteins might play a role in the control of the translocase activity. However, the positive effects of basic fibroblast growth factor, serum and high-density lipoproteins on the translocase activity were suppressed when experiments were carried out in the presence of an anti-(basic fibroblast growth factor) IgG, thus indicating that in all cases, basic fibrobiast growth factor was directly involved in the modulation of the aminophospholipid translocase activity present in the plasma membrane of bovine aortic endothelial cells." @default.
• W4247555336 created "2022-05-12" @default.
• W4247555336 creator A5026669603 @default.
• W4247555336 creator A5042250414 @default.
• W4247555336 creator A5090823192 @default.
• W4247555336 date "1995-05-01" @default.
• W4247555336 modified "2023-09-28" @default.
• W4247555336 title "Basic Fibroblast Growth Factor Modulates the Aminophospholipid Translocase Activity Present in the Plasma Membrane of Bovine Aortic Endothelial Cells" @default.
• W4247555336 cites W150899389 @default.
• W4247555336 cites W1762647466 @default.
• W4247555336 cites W1923838861 @default.
• W4247555336 cites W1980341942 @default.
• W4247555336 cites W1986638328 @default.
• W4247555336 cites W2004220826 @default.
• W4247555336 cites W2014826463 @default.
• W4247555336 cites W2015323681 @default.
• W4247555336 cites W2030001254 @default.
• W4247555336 cites W2070062282 @default.
• W4247555336 cites W2071782007 @default.
• W4247555336 cites W2082267164 @default.
• W4247555336 cites W2162740250 @default.
• W4247555336 cites W2307237767 @default.
• W4247555336 cites W4254031988 @default.
• W4247555336 doi "https://doi.org/10.1111/j.1432-1033.1995.tb20562.x" @default.
• W4247555336 hasPublicationYear "1995" @default.
• W4247555336 type Work @default.
• W4247555336 citedByCount "0" @default.
• W4247555336 crossrefType "journal-article" @default.
• W4247555336 hasAuthorship W4247555336A5026669603 @default.
• W4247555336 hasAuthorship W4247555336A5042250414 @default.
• W4247555336 hasAuthorship W4247555336A5090823192 @default.
• W4247555336 hasBestOaLocation W42475553361 @default.
• W4247555336 hasConcept C104317684 @default.
• W4247555336 hasConcept C113035283 @default.
• W4247555336 hasConcept C138626823 @default.
• W4247555336 hasConcept C185592680 @default.
• W4247555336 hasConcept C202751555 @default.
• W4247555336 hasConcept C2776330855 @default.
• W4247555336 hasConcept C2778918659 @default.
• W4247555336 hasConcept C2779637612 @default.
• W4247555336 hasConcept C2780381497 @default.
• W4247555336 hasConcept C2781170229 @default.
• W4247555336 hasConcept C39944091 @default.
• W4247555336 hasConcept C41625074 @default.
• W4247555336 hasConcept C55493867 @default.
• W4247555336 hasConcept C86803240 @default.
• W4247555336 hasConcept C95444343 @default.
• W4247555336 hasConceptScore W4247555336C104317684 @default.
• W4247555336 hasConceptScore W4247555336C113035283 @default.
• W4247555336 hasConceptScore W4247555336C138626823 @default.
• W4247555336 hasConceptScore W4247555336C185592680 @default.
• W4247555336 hasConceptScore W4247555336C202751555 @default.
• W4247555336 hasConceptScore W4247555336C2776330855 @default.
• W4247555336 hasConceptScore W4247555336C2778918659 @default.
• W4247555336 hasConceptScore W4247555336C2779637612 @default.
• W4247555336 hasConceptScore W4247555336C2780381497 @default.
• W4247555336 hasConceptScore W4247555336C2781170229 @default.
• W4247555336 hasConceptScore W4247555336C39944091 @default.
• W4247555336 hasConceptScore W4247555336C41625074 @default.
• W4247555336 hasConceptScore W4247555336C55493867 @default.
• W4247555336 hasConceptScore W4247555336C86803240 @default.
• W4247555336 hasConceptScore W4247555336C95444343 @default.
• W4247555336 hasIssue "1" @default.
• W4247555336 hasLocation W42475553361 @default.
• W4247555336 hasOpenAccess W4247555336 @default.
• W4247555336 hasPrimaryLocation W42475553361 @default.
• W4247555336 hasRelatedWork W1520073414 @default.
• W4247555336 hasRelatedWork W1926486816 @default.
• W4247555336 hasRelatedWork W1972748726 @default.
• W4247555336 hasRelatedWork W1980031417 @default.
• W4247555336 hasRelatedWork W2016583698 @default.
• W4247555336 hasRelatedWork W2053239368 @default.
• W4247555336 hasRelatedWork W2317954243 @default.
• W4247555336 hasRelatedWork W4241134902 @default.
• W4247555336 hasRelatedWork W4247288222 @default.
• W4247555336 hasRelatedWork W950194781 @default.
• W4247555336 hasVolume "230" @default.
• W4247555336 isParatext "false" @default.
• W4247555336 isRetracted "false" @default.
• W4247555336 workType "article" @default.