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- W4247563334 abstract "Tumor cells release membrane vesicles, named exosomes, capable of specific cytotoxic T-lymphocyte activation by transferring tumor antigens to dendritic cells. By contrast, the nonclassical human leucocyte antigen (HLA)-G class I molecule displays immunotolerant properties and can be ectopically expressed by tumor cells, thereby allowing their escape from immunosurveillance. We describe here that a melanoma cell line, named Fon, established from an HLA-G–positive melanoma biopsy, spontaneously expressed high levels of the HLA-G1 membrane-bound isoform. Exosomes released by Fon cells were purified and analyzed both for their density on sucrose gradient and their protein composition by Western blotting and flow cytometry. Besides the expression of well-described proteins such as Lamp-2, notably, these melanoma-derived exosomes bore HLA-G1. In addition, exosomes harboring HLA-G1 were secreted by the HLA-G–negative M8 melanoma cells transfected with the HLA-G1 cDNA. Thus, the presence of tolerogenic HLA-G molecules on melanoma-derived exosomes may provide a novel way for tumors to modulate host's immune response." @default.
- W4247563334 created "2022-05-12" @default.
- W4247563334 creator A5064705232 @default.
- W4247563334 date "2003-10-14" @default.
- W4247563334 modified "2023-09-30" @default.
- W4247563334 title "Exosomes bearing hla-g are released by melanoma cells" @default.
- W4247563334 doi "https://doi.org/10.1016/s0198-8859(03)00531-7" @default.
- W4247563334 hasPublicationYear "2003" @default.
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