Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247579369> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4247579369 endingPage "2789" @default.
- W4247579369 startingPage "2755" @default.
- W4247579369 abstract "An increasing number of persons live for nine or more decades and enjoy the benefits of a well-functioning brain until the end of their life. In that respect, the cognitive performance in later life and the quality maintenance of the brain are amazing biological phenomena. Since most nerve cells are generated during pregnancy and have to survive an active lifetime, the brain has to be endowed with a maintenance machinery of surprising long-term quality. During successful, that is, non-pathological, aging in most brain regions, there is very little or no evidence for a decrease in numbers of neurons. In some brain structures, a limited reduction of nerve cells may occur, but it is generally conceived that aging and aging-related cognitive impairments are not the result of massive cell loss but rather the result of synaptic changes, receptor dysfunction or signaling deficits, and metabolic decline. Besides, nerve cell loss during normal aging may be compensated by synaptogenesis, dendritic branching, or in certain brain structures like dentate gyrus by neurogenesis from progenitor stem cells. Yet most human individuals suffer from a mild but life-disturbing condition we call aging-related memory impairment (AMI). In this chapter, some of the mechanisms will be shortly explored that are considered to be causal to non-pathological deterioration of cognitive faculties. In particular several cellular and molecular neuronal changes will be addressed that occur during aging, the consequences for interneuronal communication and membrane potential, the blood supply to the brain and cerebrovascular condition, and some observations on the protective neuroimmune system of the brain." @default.
- W4247579369 created "2022-05-12" @default.
- W4247579369 creator A5004204177 @default.
- W4247579369 creator A5045898581 @default.
- W4247579369 creator A5063259248 @default.
- W4247579369 creator A5087863283 @default.
- W4247579369 date "2016-01-01" @default.
- W4247579369 modified "2023-09-29" @default.
- W4247579369 title "Aging of the Brain" @default.
- W4247579369 cites W1542136448 @default.
- W4247579369 cites W1973311433 @default.
- W4247579369 cites W1986898036 @default.
- W4247579369 cites W1992842030 @default.
- W4247579369 cites W1996710971 @default.
- W4247579369 cites W1998354033 @default.
- W4247579369 cites W1999304520 @default.
- W4247579369 cites W2036622325 @default.
- W4247579369 cites W2037788915 @default.
- W4247579369 cites W2057845537 @default.
- W4247579369 cites W2073748140 @default.
- W4247579369 cites W2076215391 @default.
- W4247579369 cites W2084792449 @default.
- W4247579369 cites W2094660330 @default.
- W4247579369 cites W2103769608 @default.
- W4247579369 cites W2103916699 @default.
- W4247579369 cites W2110831253 @default.
- W4247579369 cites W2111443842 @default.
- W4247579369 cites W2119302018 @default.
- W4247579369 cites W2123849072 @default.
- W4247579369 cites W2142850882 @default.
- W4247579369 cites W2150410500 @default.
- W4247579369 doi "https://doi.org/10.1007/978-1-4939-3474-4_84" @default.
- W4247579369 hasPublicationYear "2016" @default.
- W4247579369 type Work @default.
- W4247579369 citedByCount "0" @default.
- W4247579369 crossrefType "book-chapter" @default.
- W4247579369 hasAuthorship W4247579369A5004204177 @default.
- W4247579369 hasAuthorship W4247579369A5045898581 @default.
- W4247579369 hasAuthorship W4247579369A5063259248 @default.
- W4247579369 hasAuthorship W4247579369A5087863283 @default.
- W4247579369 hasBestOaLocation W42475793692 @default.
- W4247579369 hasConcept C142724271 @default.
- W4247579369 hasConcept C15744967 @default.
- W4247579369 hasConcept C169760540 @default.
- W4247579369 hasConcept C169900460 @default.
- W4247579369 hasConcept C188147891 @default.
- W4247579369 hasConcept C201750760 @default.
- W4247579369 hasConcept C207886595 @default.
- W4247579369 hasConcept C2776464000 @default.
- W4247579369 hasConcept C2779134260 @default.
- W4247579369 hasConcept C2779483572 @default.
- W4247579369 hasConcept C2779695026 @default.
- W4247579369 hasConcept C2781161787 @default.
- W4247579369 hasConcept C28328180 @default.
- W4247579369 hasConcept C2984443765 @default.
- W4247579369 hasConcept C2984863031 @default.
- W4247579369 hasConcept C4746552 @default.
- W4247579369 hasConcept C65232495 @default.
- W4247579369 hasConcept C71924100 @default.
- W4247579369 hasConcept C86803240 @default.
- W4247579369 hasConcept C95444343 @default.
- W4247579369 hasConceptScore W4247579369C142724271 @default.
- W4247579369 hasConceptScore W4247579369C15744967 @default.
- W4247579369 hasConceptScore W4247579369C169760540 @default.
- W4247579369 hasConceptScore W4247579369C169900460 @default.
- W4247579369 hasConceptScore W4247579369C188147891 @default.
- W4247579369 hasConceptScore W4247579369C201750760 @default.
- W4247579369 hasConceptScore W4247579369C207886595 @default.
- W4247579369 hasConceptScore W4247579369C2776464000 @default.
- W4247579369 hasConceptScore W4247579369C2779134260 @default.
- W4247579369 hasConceptScore W4247579369C2779483572 @default.
- W4247579369 hasConceptScore W4247579369C2779695026 @default.
- W4247579369 hasConceptScore W4247579369C2781161787 @default.
- W4247579369 hasConceptScore W4247579369C28328180 @default.
- W4247579369 hasConceptScore W4247579369C2984443765 @default.
- W4247579369 hasConceptScore W4247579369C2984863031 @default.
- W4247579369 hasConceptScore W4247579369C4746552 @default.
- W4247579369 hasConceptScore W4247579369C65232495 @default.
- W4247579369 hasConceptScore W4247579369C71924100 @default.
- W4247579369 hasConceptScore W4247579369C86803240 @default.
- W4247579369 hasConceptScore W4247579369C95444343 @default.
- W4247579369 hasLocation W42475793691 @default.
- W4247579369 hasLocation W42475793692 @default.
- W4247579369 hasOpenAccess W4247579369 @default.
- W4247579369 hasPrimaryLocation W42475793691 @default.
- W4247579369 hasRelatedWork W1543941020 @default.
- W4247579369 hasRelatedWork W1964423835 @default.
- W4247579369 hasRelatedWork W2024576858 @default.
- W4247579369 hasRelatedWork W2084184306 @default.
- W4247579369 hasRelatedWork W2128063722 @default.
- W4247579369 hasRelatedWork W2134200856 @default.
- W4247579369 hasRelatedWork W2192476518 @default.
- W4247579369 hasRelatedWork W24814652 @default.
- W4247579369 hasRelatedWork W2724488918 @default.
- W4247579369 hasRelatedWork W4312473974 @default.
- W4247579369 isParatext "false" @default.
- W4247579369 isRetracted "false" @default.
- W4247579369 workType "book-chapter" @default.