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• W4247587448 abstract "Animal Models of Movement Disorders . Mark LeDoux , ed . Amsterdam : Elsevier , 2004 , 824 pp . This handsome volume describes animal models of movement disorders, but, as the editor points out, a more fitting title would have been Animal Models of Movement Disorders and Spontaneous Mutants with Motor Dysfunction. The volume is well organized. The first section discusses the scientific foundation on which subsequent studies are formed and provides a comprehensive statement of the science approach, including how to generate transgenic and gene-targeted mouse models of movement disorders, the genetics of spontaneous mutations in mice, and assessments of movement disorders. The authors have not limited their paradigms to rodents but also discuss Drosophila and C. elegans. Each subsequent section deals with a particular disease or syndrome and describes the models that may be pertinent. The description of the models is comprehensive and allows a new investigator to approach the model with significant knowledge of the advantages, nuances, and limitations. In future editions, it would be nice to emphasize age- and sex-specific differences within the basal ganglia that would account for the expression of certain syndromes, especially those that appear to occur early in life. This approach is elegantly described in the dystonic mouse model. Hormonal and sex differences also should be examined. While reading the various models, I realized that epileptologists would greatly benefit by interacting with researchers in the field of movement disorders, and vice versa. As epilepsies and basal ganglia diseases share many common mechanisms, this volume provides much information that can be useful for researchers in both fields. Exchanges between workers in epilepsy and basal ganglia disease also may help resolve some of the issues relating to the behavior of these animals, which may be seizures, stereotypies, or other movement disorders such as dystonic posturing. As an aside, I would have liked to see more discussion about the role of substantia nigra pars reticulata in the expression of these syndromes, as it appears to be the forgotten player within the different schemata proposed for movement disorders, yet it represents a major output pathway of the basal ganglia, and it is known to have age- and sex-specific features that may help us understand movement disorders as well. A major plus for this volume is the CD that includes video clips of patients and animal models. The videos are very well presented. In a subsequent edition, the editor may consider including a voice-over for most of the behaviors shown. Undoubtedly, this volume will be of great help to all workers in the field, as well as to people interested in the basal ganglia, which now seem to play a very important role not only for the expression of movement disorders but also in epilepsy and cognition. It is a much-needed volume and a tremendous asset to all investigators." @default.
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• W4247587448 date "2005-07-01" @default.
• W4247587448 modified "2023-09-29" @default.
• W4247587448 title "Book Review" @default.
• W4247587448 doi "https://doi.org/10.1111/j.1528-1167.2005.06005.x" @default.
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