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• W4247623033 abstract "We appreciate the interest and discussion that our work about the quantification of perfusion in the murine skeletal muscle with MRI (1) receives. In their letter, Bertoldi and co-workers claim that the calculations we made to support our results taking literature values from (2) are wrong. They conclude that our results receive no back up from the literature. Since no arterial reference was taken in the work of Maxwell and co-workers, the CO could not be determined. We therefore used the CO measured by cine-MRI (3) to perform the calculation. For a mean body weight that corresponded to our animal population, the CO was determined to be 15.7 ml/min in (3). Maxwell and co-workers state that 'the hindlimb muscles were collected and weighed for determination of the microsphere density' (page 370, section 'Experimental Protocol', last phrase), the masses were then used to normalize the tissue weight to the average tissue weight of all animals. Unfortunately these values were not given in (2). However, the claim that the masses 'apparently cannot be retrieved' in the letter of Bertoldi and co-workers (personal communication between Bertoldi and Maxwell) therefore was surprising to us. However, muscle masses of the hindlimbs have been given in (4). Extracting the masses of the gastrocnemius and quadriceps muscles from one limb (the muscles the work of Maxwell and co-workers refers to) from (4) results in a total muscle mass of about 0.5 g. In our understanding, both hindlimbs were analyzed in the work of Maxwell and co-workers. As a consequence, the total muscle mass is about 1.0 g and the calculation results in a perfusion of 94 ml (100g min)-1 as published in our paper (1). The perfusion of 94 +/- 10 ml (100g min)-1 we determined with MRI shows an excellent agreement with this value. Let us assume that Maxwell and co-workers analyzed only muscles in one hindlimb. In this case, the total muscle mass would be 0.5 g and the use of equation (1) would result in a higher perfusion of 188 ml (100g min)-1 calculated from the results of Maxwell and co-workers. Of course, this would be a major contradiction to the general claim in the letter of Bertoldi and co-workers that already our mean perfusion value of 94 +/- 10 ml (100g min)-1 is too high. In contrast to the results of Maxwell and co-workers, a very recent paper determined a perfusion of 25 +/-3 ml (100g min)-1 in the gracilis muscle using fluorescent microspheres (5). This work was published after the final submission of our paper. In summary, published results of microsphere studies show a variety of perfusion in the murine hindlimbs from 25 to 94 ml (100g min)-1. The result of our first in vivo quantification of this parameter using an MRI technique is supported by the work of Maxwell and co-workers (2). We therefore reject the claim that there is no support in the literature for our work. Calculations such as those described above or in the letter of Bertoldi and co-workers are valuable as a tool to test if the results show the correct order of magnitude. This was the case for our results. Bertoldi and co-workers did not describe any specific errors of our method in their letter. To underline the accuracy of our technique, we refer to the validation against measurements made with microspheres or first pass perfusion imaging in previous studies (6, 7, 8). We look forward to discussing the results of Bertoldi and co-workers. Jörg U.G. Streif MS streif@physik.uni-wuerzburg.de*, Karl-Heinz Hiller PhD*, Christiane Waller MD*, Matthias Nahrendorf MD*, Frank Wiesmann MD*, Wolfgang R. Bauer MD*, Eberhard Rommel PhD*, Axel Haase PhD*, * Physikalisches Institut Lehrstuhl für Experimentelle Physik V (Biophysik) Universität Würzburg Am Hubland 97074 Würzburg Germany" @default.
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• W4247623033 date "2003-09-19" @default.
• W4247623033 modified "2023-09-25" @default.
• W4247623033 title "Reply" @default.
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• W4247623033 doi "https://doi.org/10.1002/jmri.10407" @default.
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