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- W4247657935 abstract "Abstract Background : We investigated the effect of the interruption time on the radiobiological effectiveness with photon beams based on a modified microdosimetric kinetic model. Background: The interruption time is used is that irradiation interruption occurs at sites and operations such as the gantry, collimator, couch rotation, and patient set-up in radiotherapy. However, the effect of interruption time on photon beams for tumor cells is little evaluated. Methods : The dose-mean lineal energy y D (keV/µm) of 6 MV photon beams was calculated by the particle and heavy ion transport system (PHITS). We set the absorbed dose to 2 or 8 Gy, and the interruption time (τ) was set to 1, 3, 5, or 10 min. The biological parameters values were acquired from a human non-small cell lung cancer cell line (NCI-H460) for the mMK model. We used two-field and four-field irradiation with a constant dose rate (3 Gy/min); the photon beams were paused for interruption time τ. We calculated the relative biological effectiveness (RBE) to evaluate the interruption time's effect compared with photon beams that were not interrupted as a reference. Results : The RBE with four-field irradiation for 8 Gy was decreased to 0.997, 0.992, 0.987, and 0.975 for τ = 1, 3, 5, and 10 min, respectively. The decrease in the RBE was within 3% compared with the non-interrupted photon beams. Conclusions : The effect of RBE was decreased by increasing the interruption time, indicating that an escalation of the prescribed dose might be necessary when the interruption time was large." @default.
- W4247657935 created "2022-05-12" @default.
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- W4247657935 date "2020-03-19" @default.
- W4247657935 modified "2023-09-27" @default.
- W4247657935 title "Radiobiological effects of the interruption time in radiation therapy with photon beams based on the microdosimetric kinetic model" @default.
- W4247657935 doi "https://doi.org/10.21203/rs.3.rs-17887/v1" @default.
- W4247657935 hasPublicationYear "2020" @default.
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