Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247698719> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4247698719 abstract "The peripheral benzodiazepine receptor (PBR) is pharmacologically distinct from the central benzodiazepine receptor (CBR) and has been identified in a wide range of peripheral tissues as well as in the central nervous system. Although numerous studies have been performed of it, the physiological roles and functions of the PBR are still unclear. In the present study, in exploring new types of ligands for PBR, we found that a new series of compounds having a tetracyclic ring system, which were designed from FGIN-1-27, exhibited high affinities for PBR. We prepared and evaluated them for PBR affinities. The results of binding tests showed that 12e and 12f were the most potent PBR ligands among them (12e: IC50=0.44 nM, 12f: IC50=0.37 nM). In this paper, we present the design, synthesis, and structure–activity relationships (SARs) of novel tetracyclic compounds." @default.
- W4247698719 created "2022-05-12" @default.
- W4247698719 creator A5016031941 @default.
- W4247698719 date "2004-05-01" @default.
- W4247698719 modified "2023-09-27" @default.
- W4247698719 title "Design, synthesis, and structure?activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands*1" @default.
- W4247698719 doi "https://doi.org/10.1016/s0968-0896(04)00314-1" @default.
- W4247698719 hasPublicationYear "2004" @default.
- W4247698719 type Work @default.
- W4247698719 citedByCount "0" @default.
- W4247698719 crossrefType "journal-article" @default.
- W4247698719 hasAuthorship W4247698719A5016031941 @default.
- W4247698719 hasConcept C114373084 @default.
- W4247698719 hasConcept C126322002 @default.
- W4247698719 hasConcept C168258287 @default.
- W4247698719 hasConcept C170493617 @default.
- W4247698719 hasConcept C185592680 @default.
- W4247698719 hasConcept C193042331 @default.
- W4247698719 hasConcept C202751555 @default.
- W4247698719 hasConcept C2777752497 @default.
- W4247698719 hasConcept C2778173252 @default.
- W4247698719 hasConcept C2780283098 @default.
- W4247698719 hasConcept C46762472 @default.
- W4247698719 hasConcept C55493867 @default.
- W4247698719 hasConcept C71240020 @default.
- W4247698719 hasConcept C71924100 @default.
- W4247698719 hasConcept C86803240 @default.
- W4247698719 hasConcept C98274493 @default.
- W4247698719 hasConceptScore W4247698719C114373084 @default.
- W4247698719 hasConceptScore W4247698719C126322002 @default.
- W4247698719 hasConceptScore W4247698719C168258287 @default.
- W4247698719 hasConceptScore W4247698719C170493617 @default.
- W4247698719 hasConceptScore W4247698719C185592680 @default.
- W4247698719 hasConceptScore W4247698719C193042331 @default.
- W4247698719 hasConceptScore W4247698719C202751555 @default.
- W4247698719 hasConceptScore W4247698719C2777752497 @default.
- W4247698719 hasConceptScore W4247698719C2778173252 @default.
- W4247698719 hasConceptScore W4247698719C2780283098 @default.
- W4247698719 hasConceptScore W4247698719C46762472 @default.
- W4247698719 hasConceptScore W4247698719C55493867 @default.
- W4247698719 hasConceptScore W4247698719C71240020 @default.
- W4247698719 hasConceptScore W4247698719C71924100 @default.
- W4247698719 hasConceptScore W4247698719C86803240 @default.
- W4247698719 hasConceptScore W4247698719C98274493 @default.
- W4247698719 hasLocation W42476987191 @default.
- W4247698719 hasOpenAccess W4247698719 @default.
- W4247698719 hasPrimaryLocation W42476987191 @default.
- W4247698719 hasRelatedWork W1985615487 @default.
- W4247698719 hasRelatedWork W2002420245 @default.
- W4247698719 hasRelatedWork W2010672805 @default.
- W4247698719 hasRelatedWork W2019972207 @default.
- W4247698719 hasRelatedWork W2068305303 @default.
- W4247698719 hasRelatedWork W2089514417 @default.
- W4247698719 hasRelatedWork W2126415581 @default.
- W4247698719 hasRelatedWork W2460222585 @default.
- W4247698719 hasRelatedWork W2950881939 @default.
- W4247698719 hasRelatedWork W4247698719 @default.
- W4247698719 isParatext "false" @default.
- W4247698719 isRetracted "false" @default.
- W4247698719 workType "article" @default.