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- W4247725275 abstract "Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs, published in vivo studies have generally not been able to demonstrate the expected therapeutically-relevant CB1-mediated effects. Thus, a greater range of molecular tools are required to allow definitive elucidation of the effects of CB1 allosteric modulation. In this study, we show a novel series of indole sulfonamides. Compounds 5e and 6c (ABD1075) had potencies of 4 and 3 nM respectively, and showed good oral exposure and CNS penetration, making them highly versatile tools for investigating the therapeutic potential of allosteric modulation of the cannabinoid system." @default.
- W4247725275 created "2022-05-12" @default.
- W4247725275 date "1990-01-01" @default.
- W4247725275 modified "2023-09-26" @default.
- W4247725275 title "Facsimile of questionnaire" @default.
- W4247725275 doi "https://doi.org/10.1016/0014-2921(90)90084-c" @default.
- W4247725275 hasPublicationYear "1990" @default.
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