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W4247728234 abstract "(The American Journal of Human Genetics 96, 597–611; April 2, 2015) In the article referenced here, Figure 6B mistakenly includes the immunohistochemical image of AKT1 for normal tissue instead of tumor tissue on the right panel. A corrected image of AKT1 for tumor tissue appears here. The authors regret the error. Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell CarcinomaZhang et al.The American Journal of Human GeneticsApril 02, 2015In BriefEsophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and the fourth most lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little of the mutational processes responsible. To identify genome-wide mutational signatures, we performed either whole-genome sequencing (WGS) or whole-exome sequencing (WES) on 104 ESCC individuals and combined our data with those of 88 previously reported samples. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in ESCC. Full-Text PDF Open Access" @default.
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W4247728234 date "2020-09-01" @default.
W4247728234 modified "2023-10-02" @default.
W4247728234 title "Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma" @default.
W4247728234 doi "https://doi.org/10.1016/j.ajhg.2020.08.012" @default.
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