Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247733892> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4247733892 endingPage "A39" @default.
- W4247733892 startingPage "A38" @default.
- W4247733892 abstract "Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. Wang Y, Singh R, Lefkowitch JH, Rigoli RM, Czaja MJ.In vitro studies of hepatocytes have implicated over-activation of c-Jun N-terminal kinase (JNK) signaling as a mechanism of tumor necrosis factor-alpha (TNF)-induced apoptosis. However, the functional significance of JNK activation and the role of specific JNK isoforms in TNF-induced hepatic apoptosis in vivo remain unclear. JNK1 and JNK2 function was, therefore, investigated in the TNF-dependent, galactosamine/lipopolysaccharide (GalN/LPS) model of liver injury. The toxin GalN converted LPS-induced JNK signaling from a transient to prolonged activation. Liver injury and mortality from GalN/LPS was equivalent in wild-type and jnk1−/− mice but markedly decreased in jnk2−/− mice. This effect was not secondary to down-regulation of TNF receptor 1 expression or TNF production. In the absence of jnk2, the caspase-dependent, TNF death pathway was blocked, as reflected by the failure of caspase-3 and -7 and poly(ADP-ribose) polymerase cleavage to occur. JNK2 was critical for activation of the mitochondrial death pathway, as in jnk2−/− mice Bid cleavage and mitochondrial translocation and cytochrome c release were markedly decreased. This effect was secondary to the failure of jnk2−/− mice to activate caspase-8. Liver injury and caspase activation were similarly decreased in jnk2 null mice after GalN/TNF treatment. Ablation of jnk2 did not inhibit GalN/LPS-induced c-Jun kinase activity, although activity was completely blocked in jnk1−/− mice. Toxic liver injury is, therefore, associated with JNK over-activation and mediated by JNK2 promotion of caspase-8 activation and the TNF mitochondrial death pathway through a mechanism independent of c-Jun kinase activity.[Abstract reproduced by permission of J Biol Chem 2006;281:15258–67]" @default.
- W4247733892 created "2022-05-12" @default.
- W4247733892 creator A5000114370 @default.
- W4247733892 creator A5021439179 @default.
- W4247733892 creator A5030521038 @default.
- W4247733892 creator A5044486570 @default.
- W4247733892 creator A5048525367 @default.
- W4247733892 creator A5081854597 @default.
- W4247733892 creator A5082786060 @default.
- W4247733892 creator A5084550900 @default.
- W4247733892 date "2011-05-01" @default.
- W4247733892 modified "2023-09-24" @default.
- W4247733892 title "SP600125 Inhibits Orthopoxviruses Replication on a JNK1/2-Independent Manner – Implication as a Potential Anti-Poxviral" @default.
- W4247733892 doi "https://doi.org/10.1016/j.antiviral.2011.03.054" @default.
- W4247733892 hasPublicationYear "2011" @default.
- W4247733892 type Work @default.
- W4247733892 citedByCount "0" @default.
- W4247733892 crossrefType "journal-article" @default.
- W4247733892 hasAuthorship W4247733892A5000114370 @default.
- W4247733892 hasAuthorship W4247733892A5021439179 @default.
- W4247733892 hasAuthorship W4247733892A5030521038 @default.
- W4247733892 hasAuthorship W4247733892A5044486570 @default.
- W4247733892 hasAuthorship W4247733892A5048525367 @default.
- W4247733892 hasAuthorship W4247733892A5081854597 @default.
- W4247733892 hasAuthorship W4247733892A5082786060 @default.
- W4247733892 hasAuthorship W4247733892A5084550900 @default.
- W4247733892 hasConcept C104317684 @default.
- W4247733892 hasConcept C12519072 @default.
- W4247733892 hasConcept C134018914 @default.
- W4247733892 hasConcept C153911025 @default.
- W4247733892 hasConcept C17991360 @default.
- W4247733892 hasConcept C181199279 @default.
- W4247733892 hasConcept C182979987 @default.
- W4247733892 hasConcept C184235292 @default.
- W4247733892 hasConcept C185592680 @default.
- W4247733892 hasConcept C190283241 @default.
- W4247733892 hasConcept C2776637226 @default.
- W4247733892 hasConcept C2779087070 @default.
- W4247733892 hasConcept C29311851 @default.
- W4247733892 hasConcept C31573885 @default.
- W4247733892 hasConcept C48297814 @default.
- W4247733892 hasConcept C55493867 @default.
- W4247733892 hasConcept C82381507 @default.
- W4247733892 hasConcept C86339819 @default.
- W4247733892 hasConcept C86803240 @default.
- W4247733892 hasConcept C95444343 @default.
- W4247733892 hasConcept C98274493 @default.
- W4247733892 hasConcept C98424977 @default.
- W4247733892 hasConceptScore W4247733892C104317684 @default.
- W4247733892 hasConceptScore W4247733892C12519072 @default.
- W4247733892 hasConceptScore W4247733892C134018914 @default.
- W4247733892 hasConceptScore W4247733892C153911025 @default.
- W4247733892 hasConceptScore W4247733892C17991360 @default.
- W4247733892 hasConceptScore W4247733892C181199279 @default.
- W4247733892 hasConceptScore W4247733892C182979987 @default.
- W4247733892 hasConceptScore W4247733892C184235292 @default.
- W4247733892 hasConceptScore W4247733892C185592680 @default.
- W4247733892 hasConceptScore W4247733892C190283241 @default.
- W4247733892 hasConceptScore W4247733892C2776637226 @default.
- W4247733892 hasConceptScore W4247733892C2779087070 @default.
- W4247733892 hasConceptScore W4247733892C29311851 @default.
- W4247733892 hasConceptScore W4247733892C31573885 @default.
- W4247733892 hasConceptScore W4247733892C48297814 @default.
- W4247733892 hasConceptScore W4247733892C55493867 @default.
- W4247733892 hasConceptScore W4247733892C82381507 @default.
- W4247733892 hasConceptScore W4247733892C86339819 @default.
- W4247733892 hasConceptScore W4247733892C86803240 @default.
- W4247733892 hasConceptScore W4247733892C95444343 @default.
- W4247733892 hasConceptScore W4247733892C98274493 @default.
- W4247733892 hasConceptScore W4247733892C98424977 @default.
- W4247733892 hasIssue "2" @default.
- W4247733892 hasLocation W42477338921 @default.
- W4247733892 hasOpenAccess W4247733892 @default.
- W4247733892 hasPrimaryLocation W42477338921 @default.
- W4247733892 hasRelatedWork W1980517164 @default.
- W4247733892 hasRelatedWork W1994682335 @default.
- W4247733892 hasRelatedWork W2000225649 @default.
- W4247733892 hasRelatedWork W2026229082 @default.
- W4247733892 hasRelatedWork W2034249182 @default.
- W4247733892 hasRelatedWork W2053387643 @default.
- W4247733892 hasRelatedWork W2067565464 @default.
- W4247733892 hasRelatedWork W2167489508 @default.
- W4247733892 hasRelatedWork W2258151687 @default.
- W4247733892 hasRelatedWork W2461664441 @default.
- W4247733892 hasVolume "90" @default.
- W4247733892 isParatext "false" @default.
- W4247733892 isRetracted "false" @default.
- W4247733892 workType "article" @default.