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- W4247747521 abstract "A major hemodynamic abnormality in hypertension is increased peripheral vascular resistance due to changes in vascular reactivity and structural remodeling. Both in vivo and in vitro data suggest that the vasoconstrictor peptide angiotensin II (Ang II) has an important role in these processes. It has been recently recognized that Ang II, in addition to having a role in the regulation of salt-fluid homeostasis, is also a growth factor and contributes to the regulation of cellular hypertrophy or proliferation and extracellular matrix formation. At the cellular level, Ang II stimulates vascular smooth muscle cell growth, increases collagen deposition, induces inflammation, increases contractility, and decreases dilation. Molecular mechanisms associated with these changes in hypertension include up-regulation of many signaling pathways, which include the following: tyrosine kinases, mitogen-activated protein kinases, RhoA/ Rho kinase, and increased generation of reactive oxygen species. In mammalian cells, Ang II mediates effects by at least two high-affinity, plasma membrane receptors, AT1 and AT2." @default.
- W4247747521 created "2022-05-12" @default.
- W4247747521 date "2006-04-19" @default.
- W4247747521 modified "2023-09-23" @default.
- W4247747521 title "Angiotensin signaling in hypertension" @default.
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- W4247747521 doi "https://doi.org/10.1201/b14627-6" @default.
- W4247747521 hasPublicationYear "2006" @default.
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