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- W4247755027 abstract "Introduction: We have previously reported the superior feasibility and safety of adjuvant S-1 plus docetaxel in patients with stage III gastric cancer during a prospective phase II study. We report 3-year follow-up data on patients enrolled in this study. Methods: A total of 62 patients with histologically confirmed stage III gastric cancer who underwent D2 gastrectomy were enrolled into this study. They received oral S-1 (80 mg/m2/day) for 2 consecutive weeks and intravenous docetaxel (40 mg/m2) on day 1, repeated every 3 weeks (one cycle). Treatment was initiated within 45 days after surgery and repeated for 8 cycles (for 6 months), followed by S-1 monotherapy (4 weeks on, 2 weeks off) until 1 year after surgery. Three-year overall survival (OS) and disease-free survival (DFS) were evaluated. Results: The OS rate at 3 years was 83.1% [95% confidence interval (CI), 74.1-93.3%] and the DFS rate at 3 years was 68.5% (95% CI, 57.7-81.3%). Subgroup analyses according to disease stage showed a 3-year OS and DFS rate of 89.7% (95% CI, 74.1-93.3%) and 76.8% (95% CI, 63.1-93.5%) for stage IIIA, and 76.5% (95% CI, 42.8-93.4%) and 59.8% (95% CI, 44.6-80.3%) for stage IIIB, respectively. Conclusion: On the basis of 3-year follow-up data, postoperative adjuvant therapy with S-1 plus docetaxel yielded promising OS and DFS in stage III gastric cancer patients who had undergone D2 gastrectomy." @default.
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- W4247755027 date "2017-06-01" @default.
- W4247755027 modified "2023-10-15" @default.
- W4247755027 title "Three-year outcomes of a phase II study of adjuvant chemotherapy with S-1 plus docetaxel for stage III gastric cancer after curative D2 gastrectomy (OGSG1002)" @default.
- W4247755027 doi "https://doi.org/10.1093/annonc/mdx261.086" @default.
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