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- W4247764974 abstract "In a single-blind trial 29 patients with corticosteroid-dependent asthma reduced their daily dose of oral prednisolone by i mg/week while using a placebo inhaler until an unacceptable degree of asthma occurred. Betamethasone-17-valerate in a dose of 800 μg/day and if necessary 16oo μg/day was then substituted for the placebo inhaler and the reduction of oral prednisolone continued until the prednisolone was withdrawn completley or an unacceptable degree of asthma recurred. In 22 patients (76%) prednisolone was withdrawn completely, i i on 800 μg and ii on 16oo μg betamethasone-17-valerate. The mean reduction of prednisolone was 3·8 mg on placebo, 5·4 mg on 800 μg and a further 1·8 mg in patients requiring i 600 μg of betamethasone-17-valerate. The hypothalamic pituitary adrenal (HPA) axis was assessed by tetracosactrin and insulin stress tests at the start of the study and after withdrawal of oral prednisolone. The results indicate that an HPA axis which is completely suppressed by systemic corticosteroids can regain normal integrity when the systemic steroid is replaced by betamethasone-17-valerate in a dose of either 8oo μg/day or i6oo μg/day. Candidiasis was observed, but will be reported later." @default.
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- W4247764974 date "1975-10-01" @default.
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- W4247764974 doi "https://doi.org/10.1016/s0007-0971(75)80040-4" @default.
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