Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247767319> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4247767319 endingPage "1069" @default.
- W4247767319 startingPage "1062" @default.
- W4247767319 abstract "Somatostatin receptors (sstr) subtypes 1–5 were transiently expressed in NIH 3T3 cells stably transformed with Ha-RasG12V to assess the ability of each receptor to stimulate protein tyrosine phosphatase (PTPase) activity in vitro. Treatment of membranes from sstr2-, sstr3-, or sstr4-expressing cells with somatostatin-14 plus guanyl-5′-yl imidodiphosphate (GMPPNP) increased PTPase activity, and this stimulation was pertussis toxin-sensitive. Somatostatin alone, GMPPNP alone, or somatostatin plus GDP were ineffective under these conditions. sstr1 and sstr5 failed to increase PTPase activity although both receptors were expressed, as assessed by appearance of high-affinity binding sites for[ 125I-Tyr11]somatostatin-14. Somatostatin plus GMPPNP stimulated PTPase activity in vitro when sstr2 was coexpressed with wild type PTP1B or a Cys to Ser (C/S), catalytically inactive PTP1B or with wild type SH2-domain containing PTPase SHP-2. However, coexpression with catalytically inactive C/S SHP-2 abrogated this response. Thus, three of the five cloned sstr’s can couple to activate PTPase in this cellular background. Abrogation of the response by C/S SHP-2 strongly suggests, but does not prove, a role for SHP-2 in the mechanism." @default.
- W4247767319 created "2022-05-12" @default.
- W4247767319 creator A5072141278 @default.
- W4247767319 date "1997-07-01" @default.
- W4247767319 modified "2023-10-16" @default.
- W4247767319 title "Activation In Vitro of Somatostatin Receptor Subtypes 2, 3, or 4 Stimulates Protein Tyrosine Phosphatase Activity in Membranes from Transfected Ras-Transformed NIH 3T3 Cells: Coexpression with Catalytically Inactive SHP-2 Blocks Responsiveness" @default.
- W4247767319 doi "https://doi.org/10.1210/me.11.8.1062" @default.
- W4247767319 hasPublicationYear "1997" @default.
- W4247767319 type Work @default.
- W4247767319 citedByCount "19" @default.
- W4247767319 countsByYear W42477673192012 @default.
- W4247767319 countsByYear W42477673192013 @default.
- W4247767319 countsByYear W42477673192018 @default.
- W4247767319 crossrefType "journal-article" @default.
- W4247767319 hasAuthorship W4247767319A5072141278 @default.
- W4247767319 hasBestOaLocation W42477673191 @default.
- W4247767319 hasConcept C104317684 @default.
- W4247767319 hasConcept C11960822 @default.
- W4247767319 hasConcept C134018914 @default.
- W4247767319 hasConcept C150008808 @default.
- W4247767319 hasConcept C153911025 @default.
- W4247767319 hasConcept C170493617 @default.
- W4247767319 hasConcept C178666793 @default.
- W4247767319 hasConcept C202751555 @default.
- W4247767319 hasConcept C2776297358 @default.
- W4247767319 hasConcept C32363146 @default.
- W4247767319 hasConcept C49773422 @default.
- W4247767319 hasConcept C54009773 @default.
- W4247767319 hasConcept C55493867 @default.
- W4247767319 hasConcept C64980429 @default.
- W4247767319 hasConcept C80115893 @default.
- W4247767319 hasConcept C80631254 @default.
- W4247767319 hasConcept C85528070 @default.
- W4247767319 hasConcept C86803240 @default.
- W4247767319 hasConcept C95444343 @default.
- W4247767319 hasConceptScore W4247767319C104317684 @default.
- W4247767319 hasConceptScore W4247767319C11960822 @default.
- W4247767319 hasConceptScore W4247767319C134018914 @default.
- W4247767319 hasConceptScore W4247767319C150008808 @default.
- W4247767319 hasConceptScore W4247767319C153911025 @default.
- W4247767319 hasConceptScore W4247767319C170493617 @default.
- W4247767319 hasConceptScore W4247767319C178666793 @default.
- W4247767319 hasConceptScore W4247767319C202751555 @default.
- W4247767319 hasConceptScore W4247767319C2776297358 @default.
- W4247767319 hasConceptScore W4247767319C32363146 @default.
- W4247767319 hasConceptScore W4247767319C49773422 @default.
- W4247767319 hasConceptScore W4247767319C54009773 @default.
- W4247767319 hasConceptScore W4247767319C55493867 @default.
- W4247767319 hasConceptScore W4247767319C64980429 @default.
- W4247767319 hasConceptScore W4247767319C80115893 @default.
- W4247767319 hasConceptScore W4247767319C80631254 @default.
- W4247767319 hasConceptScore W4247767319C85528070 @default.
- W4247767319 hasConceptScore W4247767319C86803240 @default.
- W4247767319 hasConceptScore W4247767319C95444343 @default.
- W4247767319 hasIssue "8" @default.
- W4247767319 hasLocation W42477673191 @default.
- W4247767319 hasOpenAccess W4247767319 @default.
- W4247767319 hasPrimaryLocation W42477673191 @default.
- W4247767319 hasRelatedWork W1512913021 @default.
- W4247767319 hasRelatedWork W1568509230 @default.
- W4247767319 hasRelatedWork W1586440320 @default.
- W4247767319 hasRelatedWork W1864145667 @default.
- W4247767319 hasRelatedWork W2046702994 @default.
- W4247767319 hasRelatedWork W2074658847 @default.
- W4247767319 hasRelatedWork W2219152271 @default.
- W4247767319 hasRelatedWork W2324752751 @default.
- W4247767319 hasRelatedWork W2413517490 @default.
- W4247767319 hasRelatedWork W4230523305 @default.
- W4247767319 hasVolume "11" @default.
- W4247767319 isParatext "false" @default.
- W4247767319 isRetracted "false" @default.
- W4247767319 workType "article" @default.