Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247783105> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4247783105 endingPage "502" @default.
- W4247783105 startingPage "473" @default.
- W4247783105 abstract "Extrapolation of the regional dose of an inhaled xenobiotic from laboratory animals to humans for purposes of assessing human health risk is problematic because of large interspecies differences in nasal respiratory physiology and airway anatomy. There is a need for dosimetry models that can adjust for these differences in the upper respiratory tract. The present work extends previous efforts in this laboratory and elsewhere to simulate nasal airflow profiles numerically in laboratory animals and humans. A three-dimensional, anatomically accurate representation of an adult human nasal cavity and nasopharynx was constructed. The Navier-Stokes and continuity equations for airflow were solved using the finite-element method under steady-state, inspiratory conditions simulating rest and light exercise (steady-state inspiratory flow rates: 15 L/min and 26 L/min, respectively) with the fluid dynamics software package FIDAP. Simulated airflow was streamlined in the main nasal passages and complex in the vestibule and nasopharynx. Swirling air currents and recirculating flow were predicted in the nasal vestibule, and the expansion at the nasopharynx gave rise to two downward, countercurrent, spiraling vortices. Significant lateral flow was observed mainly in the middle lateral meatus. Flow apportionment among different regions of the nose remained almost unchanged between the two inspiratory rates simulated. Fastest flow occurred in the posterior nasal valve region. In the main nasal airway, the highest airspeeds occurred through the ventral and middle medial regions. Simulated velocity fields and pressure drops across the nasal cavity generally agreed with experimental results from the literature. It is proposed that this model can be used to reduce uncertainty in human health risk assessment for inhaled materials and to assess changes in airflow and nasal resistance due to common surgical procedures and medical conditions." @default.
- W4247783105 created "2022-05-12" @default.
- W4247783105 creator A5059858927 @default.
- W4247783105 date "1998-01-01" @default.
- W4247783105 modified "2023-10-12" @default.
- W4247783105 title "COMPUTATIONAL FLUID DYNAMICS SIMULATIONS OF INSPIRATORY AIRFLOW IN THE HUMAN NOSE AND NASOPHARYNX" @default.
- W4247783105 cites W1781489658 @default.
- W4247783105 cites W1852329889 @default.
- W4247783105 cites W1968723504 @default.
- W4247783105 cites W1995830958 @default.
- W4247783105 cites W2005359447 @default.
- W4247783105 cites W2012882262 @default.
- W4247783105 cites W2074640057 @default.
- W4247783105 cites W2076074467 @default.
- W4247783105 cites W2086810664 @default.
- W4247783105 cites W2093962613 @default.
- W4247783105 cites W2325602329 @default.
- W4247783105 cites W2329268468 @default.
- W4247783105 cites W2914187023 @default.
- W4247783105 cites W4323053494 @default.
- W4247783105 doi "https://doi.org/10.1080/089583798197637" @default.
- W4247783105 hasPublicationYear "1998" @default.
- W4247783105 type Work @default.
- W4247783105 citedByCount "14" @default.
- W4247783105 countsByYear W42477831052014 @default.
- W4247783105 countsByYear W42477831052016 @default.
- W4247783105 countsByYear W42477831052018 @default.
- W4247783105 countsByYear W42477831052020 @default.
- W4247783105 crossrefType "journal-article" @default.
- W4247783105 hasAuthorship W4247783105A5059858927 @default.
- W4247783105 hasConcept C105702510 @default.
- W4247783105 hasConcept C105922876 @default.
- W4247783105 hasConcept C116067010 @default.
- W4247783105 hasConcept C121332964 @default.
- W4247783105 hasConcept C2778302484 @default.
- W4247783105 hasConcept C2778311950 @default.
- W4247783105 hasConcept C2778801703 @default.
- W4247783105 hasConcept C2779644171 @default.
- W4247783105 hasConcept C38349280 @default.
- W4247783105 hasConcept C42219234 @default.
- W4247783105 hasConcept C534529494 @default.
- W4247783105 hasConcept C57879066 @default.
- W4247783105 hasConcept C71924100 @default.
- W4247783105 hasConcept C97355855 @default.
- W4247783105 hasConceptScore W4247783105C105702510 @default.
- W4247783105 hasConceptScore W4247783105C105922876 @default.
- W4247783105 hasConceptScore W4247783105C116067010 @default.
- W4247783105 hasConceptScore W4247783105C121332964 @default.
- W4247783105 hasConceptScore W4247783105C2778302484 @default.
- W4247783105 hasConceptScore W4247783105C2778311950 @default.
- W4247783105 hasConceptScore W4247783105C2778801703 @default.
- W4247783105 hasConceptScore W4247783105C2779644171 @default.
- W4247783105 hasConceptScore W4247783105C38349280 @default.
- W4247783105 hasConceptScore W4247783105C42219234 @default.
- W4247783105 hasConceptScore W4247783105C534529494 @default.
- W4247783105 hasConceptScore W4247783105C57879066 @default.
- W4247783105 hasConceptScore W4247783105C71924100 @default.
- W4247783105 hasConceptScore W4247783105C97355855 @default.
- W4247783105 hasIssue "5" @default.
- W4247783105 hasLocation W42477831051 @default.
- W4247783105 hasOpenAccess W4247783105 @default.
- W4247783105 hasPrimaryLocation W42477831051 @default.
- W4247783105 hasRelatedWork W1977583615 @default.
- W4247783105 hasRelatedWork W207796001 @default.
- W4247783105 hasRelatedWork W2283613044 @default.
- W4247783105 hasRelatedWork W2351141107 @default.
- W4247783105 hasRelatedWork W2378691469 @default.
- W4247783105 hasRelatedWork W2760168677 @default.
- W4247783105 hasRelatedWork W2905207482 @default.
- W4247783105 hasRelatedWork W2955800344 @default.
- W4247783105 hasRelatedWork W4229368976 @default.
- W4247783105 hasRelatedWork W4239578094 @default.
- W4247783105 hasVolume "10" @default.
- W4247783105 isParatext "false" @default.
- W4247783105 isRetracted "false" @default.
- W4247783105 workType "article" @default.