Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247788266> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4247788266 endingPage "514" @default.
- W4247788266 startingPage "500" @default.
- W4247788266 abstract "Fifty-seven patients with amyotrophic lateral sclerosis (ALS) were randomly assigned to receive single subcutaneous doses of 0.5, 1, 3, 7, 10, or 30 micrograms/kg recombinant human ciliary neurotrophic factor (rHCNTF) or placebo. Peak plasma concentrations occurred 180 to 260 min after dosing. rHCNTF plasma concentrations then appeared to decay, with an apparent elimination half-life of 120-400 min. Eight of 12 patients who received the highest dose had measurable plasma rHCNTF levels 24 h after dosing. Peak plasma concentrations of rHCNTF in patients receiving 30 micrograms/kg rHCNTF were in the range that has been shown to support the survival of embryonic rat and human motor neurons in tissue culture. Systemic exposure to rHCNTF increased with increasing dose. The elimination of rHCNTF, over the dose range evaluated, appeared to follow first-order processes. Elevations in body temperature and evidence of activation of the acute phase response were observed." @default.
- W4247788266 created "2022-05-12" @default.
- W4247788266 creator A9999999999 @default.
- W4247788266 date "1995-12-01" @default.
- W4247788266 modified "2023-09-29" @default.
- W4247788266 title "The Pharmacokinetics of Subcutaneously Administered Recombinant Human Ciliary Neurotrophic Factor (rHCNTF) in Patients with Amyotrophic Lateral Sclerosis" @default.
- W4247788266 doi "https://doi.org/10.1097/00002826-199512000-00003" @default.
- W4247788266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8681311" @default.
- W4247788266 hasPublicationYear "1995" @default.
- W4247788266 type Work @default.
- W4247788266 citedByCount "43" @default.
- W4247788266 countsByYear W42477882662012 @default.
- W4247788266 countsByYear W42477882662014 @default.
- W4247788266 countsByYear W42477882662015 @default.
- W4247788266 countsByYear W42477882662016 @default.
- W4247788266 countsByYear W42477882662017 @default.
- W4247788266 countsByYear W42477882662023 @default.
- W4247788266 crossrefType "journal-article" @default.
- W4247788266 hasAuthorship W4247788266A9999999999 @default.
- W4247788266 hasConcept C112705442 @default.
- W4247788266 hasConcept C126322002 @default.
- W4247788266 hasConcept C134018914 @default.
- W4247788266 hasConcept C142724271 @default.
- W4247788266 hasConcept C160539049 @default.
- W4247788266 hasConcept C170493617 @default.
- W4247788266 hasConcept C204787440 @default.
- W4247788266 hasConcept C27081682 @default.
- W4247788266 hasConcept C2777288759 @default.
- W4247788266 hasConcept C2779134260 @default.
- W4247788266 hasConcept C2780596555 @default.
- W4247788266 hasConcept C42219234 @default.
- W4247788266 hasConcept C68710172 @default.
- W4247788266 hasConcept C71924100 @default.
- W4247788266 hasConcept C98274493 @default.
- W4247788266 hasConceptScore W4247788266C112705442 @default.
- W4247788266 hasConceptScore W4247788266C126322002 @default.
- W4247788266 hasConceptScore W4247788266C134018914 @default.
- W4247788266 hasConceptScore W4247788266C142724271 @default.
- W4247788266 hasConceptScore W4247788266C160539049 @default.
- W4247788266 hasConceptScore W4247788266C170493617 @default.
- W4247788266 hasConceptScore W4247788266C204787440 @default.
- W4247788266 hasConceptScore W4247788266C27081682 @default.
- W4247788266 hasConceptScore W4247788266C2777288759 @default.
- W4247788266 hasConceptScore W4247788266C2779134260 @default.
- W4247788266 hasConceptScore W4247788266C2780596555 @default.
- W4247788266 hasConceptScore W4247788266C42219234 @default.
- W4247788266 hasConceptScore W4247788266C68710172 @default.
- W4247788266 hasConceptScore W4247788266C71924100 @default.
- W4247788266 hasConceptScore W4247788266C98274493 @default.
- W4247788266 hasIssue "6" @default.
- W4247788266 hasLocation W42477882661 @default.
- W4247788266 hasLocation W42477882662 @default.
- W4247788266 hasOpenAccess W4247788266 @default.
- W4247788266 hasPrimaryLocation W42477882661 @default.
- W4247788266 hasRelatedWork W1537759556 @default.
- W4247788266 hasRelatedWork W1584967455 @default.
- W4247788266 hasRelatedWork W1971782285 @default.
- W4247788266 hasRelatedWork W1982232718 @default.
- W4247788266 hasRelatedWork W1987530196 @default.
- W4247788266 hasRelatedWork W2000620675 @default.
- W4247788266 hasRelatedWork W2004325424 @default.
- W4247788266 hasRelatedWork W2086317124 @default.
- W4247788266 hasRelatedWork W2793520024 @default.
- W4247788266 hasRelatedWork W2092333593 @default.
- W4247788266 hasVolume "18" @default.
- W4247788266 isParatext "false" @default.
- W4247788266 isRetracted "false" @default.
- W4247788266 workType "article" @default.