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- W4247794967 abstract "Tetrahydrobiopterin is a critical cofactor for the NO synthases, and in its absence these enzymes become “uncoupled,” producing reactive oxygen species (ROSs) rather than NO. In aortas of mice with deoxycorticosterone acetate–salt (DOCA-salt) hypertension, ROS production from NO synthase is markedly increased, and tetrahydrobiopterin oxidation is evident. Using mice deficient in the NADPH oxidase subunit p47phox and mice lacking either the endothelial or neuronal NO synthase, we obtained evidence that hypertension produces a cascade involving production of ROSs from the NADPH oxidase leading to oxidation of tetrahydrobiopterin and uncoupling of endothelial NO synthase (eNOS). This decreases NO production and increases ROS production from eNOS. Treatment of mice with oral tetrahydrobiopterin reduces vascular ROS production, increases NO production as determined by electron spin resonance measurements of nitrosyl hemoglobin, and blunts the increase in blood pressure due to DOCA-salt hypertension. Endothelium-dependent vasodilation is only minimally altered in vessels of mice with DOCA-salt hypertension but seems to be mediated by hydrogen peroxide released from uncoupled eNOS, since it is inhibited by catalase. Tetrahydrobiopterin oxidation may represent an important abnormality in hypertension. Treatment strategies that increase tetrahydrobiopterin or prevent its oxidation may prove useful in preventing vascular complications of this common disease." @default.
- W4247794967 created "2022-05-12" @default.
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- W4247794967 date "2003-04-15" @default.
- W4247794967 modified "2023-10-14" @default.
- W4247794967 title "Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension" @default.
- W4247794967 cites W1879535988 @default.
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- W4247794967 cites W1968354711 @default.
- W4247794967 cites W1974248143 @default.
- W4247794967 cites W1975199357 @default.
- W4247794967 cites W1978245407 @default.
- W4247794967 cites W1982047009 @default.
- W4247794967 cites W1982581996 @default.
- W4247794967 cites W1988803492 @default.
- W4247794967 cites W2009013636 @default.
- W4247794967 cites W2010715396 @default.
- W4247794967 cites W2013557200 @default.
- W4247794967 cites W2026425756 @default.
- W4247794967 cites W2029491963 @default.
- W4247794967 cites W2030277350 @default.
- W4247794967 cites W2031273373 @default.
- W4247794967 cites W2038978204 @default.
- W4247794967 cites W2039184452 @default.
- W4247794967 cites W2041075406 @default.
- W4247794967 cites W2045773814 @default.
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- W4247794967 doi "https://doi.org/10.1172/jci200314172" @default.
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