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- W4247799503 abstract "The quasispecies theory was first intended to capture the population dynamics of early replicons in the origins of life. Fundamentally equivalent to previously formulated population genetics models, it mainly studies the balance between the incessant generation of deleterious mutations and natural selection favoring the fittest types. However, due to its emphasis on short genomes and error-prone replication, it soon became a standard for RNA virus evolution. RNA viruses are useful tools for experimentally addressing basic evolutionary questions which have nonetheless practical implications for the design of rational antiviral strategies. The evolution of RNA viruses is governed by key features such as their fast replication, high per-base mutation rates, compacted genomes, poor robustness to mutation, stressed fitness tradeoffs, antagonistic epistasis, elevated particle counts, and strong transmission bottlenecks. While most of their evolutionary behavior is well explained by classical population genetics, the quasispecies theory makes some specific predictions relevant to the evolution of RNA viruses, such as the ability to evolve increased robustness in response to mutagenic treatments. Other predictions, such as the existence of an error catastrophe, still need to be further examined both theoretically and experimentally." @default.
- W4247799503 created "2022-05-12" @default.
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- W4247799503 date "2008-01-01" @default.
- W4247799503 modified "2023-09-26" @default.
- W4247799503 title "Quasispecies" @default.
- W4247799503 doi "https://doi.org/10.1016/b978-012374410-4.00481-7" @default.
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