FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247829753> ?p ?o ?g. }

• W4247829753 endingPage "863" @default.
• W4247829753 startingPage "858" @default.
• W4247829753 abstract "Summary Aldosterone has been shown to mediate p21‐dependent cellular senescence in rat kidney proximal tubules in vivo and in cultured human proximal tubular cells. The p21‐induced senescent cells express higher levels of apoptotic cytokines, such as tumour necrosis factor ( TNF )‐α compared with non‐senescent cells. The aim of the present study was to investigate the hypothesis that aldosterone increases proximal tubular apoptosis by increasing the secretion of apoptosis–inducing factors through a p21‐dependent mechanism. Human proximal tubular cells were incubated with aldosterone (10 nmol/L) and cell senescence was detected by senescence‐associated β‐galactosidase staining and expression of p21. Apoptosis was analysed by terminal deoxyribonucleotidyl transferase‐mediated dUTP –digoxigenin nick end‐labelling and annexin/propidium iodide staining, whereas p21 localization was determined by immunofluorescence. Exposure of cells to aldosterone for 3 or 5 days increased senescence–associated β‐galactosidase staining, p21 and TNF ‐α mRNA expression and secretion of TNF ‐α into the culture medium. These changes were abolished by gene silencing of p21. Aldosterone failed to increase the number of apoptotic cells on day 3, but did increase them on day 5. A neutralizing antibody against TNF ‐α prevented the aldosterone‐induced apoptotic changes. Aldosterone did not affect localization of p21. These findings indicate that aldosterone increases TNF ‐α synthesis and secretion in proximal tubular cells via p21/senescence–dependent cell phenotypic changes and that the TNF ‐α secreted plays an important role as a paracrine factor in mediating cell apoptosis, indicating a possible involvement in aldosterone‐induced renal damage." @default.
• W4247829753 created "2022-05-12" @default.
• W4247829753 creator A5004704949 @default.
• W4247829753 creator A5017931660 @default.
• W4247829753 creator A5027623025 @default.
• W4247829753 creator A5040757849 @default.
• W4247829753 creator A5044561354 @default.
• W4247829753 creator A5049403883 @default.
• W4247829753 creator A5049861668 @default.
• W4247829753 creator A5079347696 @default.
• W4247829753 date "2012-09-26" @default.
• W4247829753 modified "2023-09-26" @default.
• W4247829753 title "Aldosterone induces p21-regulated apoptosis via increased synthesis and secretion of tumour necrosis factor-<i>α</i>in human proximal tubular cells" @default.
• W4247829753 cites W1504176593 @default.
• W4247829753 cites W1711415098 @default.
• W4247829753 cites W1948291665 @default.
• W4247829753 cites W1965354428 @default.
• W4247829753 cites W1969905245 @default.
• W4247829753 cites W1981329525 @default.
• W4247829753 cites W1981389244 @default.
• W4247829753 cites W1985359885 @default.
• W4247829753 cites W1986527379 @default.
• W4247829753 cites W1992995768 @default.
• W4247829753 cites W2010766274 @default.
• W4247829753 cites W2011921507 @default.
• W4247829753 cites W2014888569 @default.
• W4247829753 cites W2020771162 @default.
• W4247829753 cites W2036389134 @default.
• W4247829753 cites W2046298859 @default.
• W4247829753 cites W2052157438 @default.
• W4247829753 cites W2062388985 @default.
• W4247829753 cites W2069519394 @default.
• W4247829753 cites W2078529879 @default.
• W4247829753 cites W2086262697 @default.
• W4247829753 cites W2091004154 @default.
• W4247829753 cites W2108592175 @default.
• W4247829753 cites W2123408027 @default.
• W4247829753 cites W2126306109 @default.
• W4247829753 cites W2129195239 @default.
• W4247829753 cites W2144862658 @default.
• W4247829753 cites W2152094259 @default.
• W4247829753 cites W2153285219 @default.
• W4247829753 cites W2154144678 @default.
• W4247829753 cites W2154797232 @default.
• W4247829753 cites W2155147356 @default.
• W4247829753 cites W2159020799 @default.
• W4247829753 cites W2163090385 @default.
• W4247829753 cites W2166068071 @default.
• W4247829753 cites W2167918360 @default.
• W4247829753 cites W2171126403 @default.
• W4247829753 cites W2323458614 @default.
• W4247829753 doi "https://doi.org/10.1111/j.1440-1681.2012.12001.x" @default.
• W4247829753 hasPublicationYear "2012" @default.
• W4247829753 type Work @default.
• W4247829753 citedByCount "12" @default.
• W4247829753 countsByYear W42478297532013 @default.
• W4247829753 countsByYear W42478297532014 @default.
• W4247829753 countsByYear W42478297532015 @default.
• W4247829753 countsByYear W42478297532017 @default.
• W4247829753 countsByYear W42478297532018 @default.
• W4247829753 countsByYear W42478297532019 @default.
• W4247829753 countsByYear W42478297532021 @default.
• W4247829753 countsByYear W42478297532023 @default.
• W4247829753 crossrefType "journal-article" @default.
• W4247829753 hasAuthorship W4247829753A5004704949 @default.
• W4247829753 hasAuthorship W4247829753A5017931660 @default.
• W4247829753 hasAuthorship W4247829753A5027623025 @default.
• W4247829753 hasAuthorship W4247829753A5040757849 @default.
• W4247829753 hasAuthorship W4247829753A5044561354 @default.
• W4247829753 hasAuthorship W4247829753A5049403883 @default.
• W4247829753 hasAuthorship W4247829753A5049861668 @default.
• W4247829753 hasAuthorship W4247829753A5079347696 @default.
• W4247829753 hasConcept C126322002 @default.
• W4247829753 hasConcept C134018914 @default.
• W4247829753 hasConcept C170493617 @default.
• W4247829753 hasConcept C17991360 @default.
• W4247829753 hasConcept C190283241 @default.
• W4247829753 hasConcept C2775934118 @default.
• W4247829753 hasConcept C2778525890 @default.
• W4247829753 hasConcept C31573885 @default.
• W4247829753 hasConcept C49039625 @default.
• W4247829753 hasConcept C522857546 @default.
• W4247829753 hasConcept C55493867 @default.
• W4247829753 hasConcept C71924100 @default.
• W4247829753 hasConcept C7876069 @default.
• W4247829753 hasConcept C86803240 @default.
• W4247829753 hasConcept C88634738 @default.
• W4247829753 hasConcept C95444343 @default.
• W4247829753 hasConceptScore W4247829753C126322002 @default.
• W4247829753 hasConceptScore W4247829753C134018914 @default.
• W4247829753 hasConceptScore W4247829753C170493617 @default.
• W4247829753 hasConceptScore W4247829753C17991360 @default.
• W4247829753 hasConceptScore W4247829753C190283241 @default.
• W4247829753 hasConceptScore W4247829753C2775934118 @default.
• W4247829753 hasConceptScore W4247829753C2778525890 @default.
• W4247829753 hasConceptScore W4247829753C31573885 @default.
• W4247829753 hasConceptScore W4247829753C49039625 @default.
• W4247829753 hasConceptScore W4247829753C522857546 @default.

• next