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- W4247829772 abstract "Tissue-type plasminogen activator (t-PA) is involved in the lysis of blood clots (fibrinolysis) and is used clinically for this purpose. Endothelial cells are one source of the t-PA present in blood. We report here that interleukin-4 (IL-4) (0.1 to 0.25 U/mL; 1 to 3 x 10(- 11) mol/L), but not interferon-gamma (IFN-gamma), elevates t-PA messenger (m)RNA expression and secretion of t-PA activity by human monocytes, with the maximum response at 2.5 U/mL. Supernatant t-PA activity was detected within three hours of exposure to IL-4 and maximum activity within six hours. Thus, IL-4 may control fibrin deposition at sites of inflammation during cell-mediated immune responses, as well as having a therapeutic role in thrombolysis." @default.
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- W4247829772 date "1989-09-01" @default.
- W4247829772 modified "2023-09-27" @default.
- W4247829772 title "Interleukin-4 stimulates human monocytes to produce tissue-type plasminogen activator" @default.
- W4247829772 doi "https://doi.org/10.1182/blood.v74.4.1222.bloodjournal7441222" @default.
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