Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247875888> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4247875888 endingPage "141" @default.
- W4247875888 startingPage "131" @default.
- W4247875888 abstract "There is evidence both from in vivo and in vitro studies which suggests that hypoxia stimulates the synthesis of prostanoids in some tissues. In the present study, the in vitro production of prostaglandin E2 (PGE2) was studied in three different renal cell lines incubated at various PO2 values between 143 and 3 mm Hg for 24 h. In rat kidney mesangial cell cultures, PGE2 production increased up to 99 ng PGE2/mg protein at 7 mm Hg O2, compared to 52 ng/mg at 143 mm Hg O2, but was lowered to 26 ng/mg at 3 mm Hg O2. PGE2 production by the pig kidney tubule cell lines LLC-PK1 and PK-15 was insensitive to PO2 changes. Because PGE2 production is known to be Ca2+-dependent and was indeed stimulated by the Ca-ionophore A 23187, effects of hypoxia on 45Ca2+-fluxes were also studied. In none of the 3 cell lines, net 45Ca-influx was altered after incubation at low PO2. However, net 45Ca-efflux increased during hypoxic incubation of mesangial cells possibly as a result of intracellular Ca-mobilization. These results indicate that hypoxia stimulates PGE2 synthesis in mesangial but not in tubule cell cultures. However, at very low PO2 values, or anoxia, the formation of cyclic endoperoxides from arachidonic acid may be lowered. Since mesangiocytes are smooth muscle-like cells, the hypoxia-induced synthesis of relaxing prostanoids could play a role in the regulation of smooth muscle tone." @default.
- W4247875888 created "2022-05-12" @default.
- W4247875888 creator A5005625193 @default.
- W4247875888 creator A5062149330 @default.
- W4247875888 date "1987-01-01" @default.
- W4247875888 modified "2023-10-13" @default.
- W4247875888 title "Effect of PO2 on prostaglandin E2 production in renal cell cultures" @default.
- W4247875888 cites W1786967371 @default.
- W4247875888 cites W1945199177 @default.
- W4247875888 cites W1963913820 @default.
- W4247875888 cites W1982943103 @default.
- W4247875888 cites W2001892445 @default.
- W4247875888 cites W2031868532 @default.
- W4247875888 cites W2049340455 @default.
- W4247875888 cites W2050153818 @default.
- W4247875888 cites W2051206683 @default.
- W4247875888 cites W2069594046 @default.
- W4247875888 cites W2076469608 @default.
- W4247875888 cites W2080728750 @default.
- W4247875888 cites W2089693058 @default.
- W4247875888 cites W2102030642 @default.
- W4247875888 cites W2113943014 @default.
- W4247875888 cites W2145942173 @default.
- W4247875888 cites W2176463262 @default.
- W4247875888 cites W2288474826 @default.
- W4247875888 cites W2330188593 @default.
- W4247875888 doi "https://doi.org/10.1016/s0034-5687(87)80038-5" @default.
- W4247875888 hasPublicationYear "1987" @default.
- W4247875888 type Work @default.
- W4247875888 citedByCount "9" @default.
- W4247875888 countsByYear W42478758882013 @default.
- W4247875888 crossrefType "journal-article" @default.
- W4247875888 hasAuthorship W4247875888A5005625193 @default.
- W4247875888 hasAuthorship W4247875888A5062149330 @default.
- W4247875888 hasConcept C126322002 @default.
- W4247875888 hasConcept C134018914 @default.
- W4247875888 hasConcept C150903083 @default.
- W4247875888 hasConcept C178790620 @default.
- W4247875888 hasConcept C181199279 @default.
- W4247875888 hasConcept C185592680 @default.
- W4247875888 hasConcept C202751555 @default.
- W4247875888 hasConcept C207001950 @default.
- W4247875888 hasConcept C25642318 @default.
- W4247875888 hasConcept C2777198256 @default.
- W4247875888 hasConcept C2777956040 @default.
- W4247875888 hasConcept C2778078955 @default.
- W4247875888 hasConcept C2779131090 @default.
- W4247875888 hasConcept C2780091579 @default.
- W4247875888 hasConcept C2780664492 @default.
- W4247875888 hasConcept C540031477 @default.
- W4247875888 hasConcept C54355233 @default.
- W4247875888 hasConcept C55493867 @default.
- W4247875888 hasConcept C71924100 @default.
- W4247875888 hasConcept C7836513 @default.
- W4247875888 hasConcept C79879829 @default.
- W4247875888 hasConcept C81885089 @default.
- W4247875888 hasConcept C86803240 @default.
- W4247875888 hasConceptScore W4247875888C126322002 @default.
- W4247875888 hasConceptScore W4247875888C134018914 @default.
- W4247875888 hasConceptScore W4247875888C150903083 @default.
- W4247875888 hasConceptScore W4247875888C178790620 @default.
- W4247875888 hasConceptScore W4247875888C181199279 @default.
- W4247875888 hasConceptScore W4247875888C185592680 @default.
- W4247875888 hasConceptScore W4247875888C202751555 @default.
- W4247875888 hasConceptScore W4247875888C207001950 @default.
- W4247875888 hasConceptScore W4247875888C25642318 @default.
- W4247875888 hasConceptScore W4247875888C2777198256 @default.
- W4247875888 hasConceptScore W4247875888C2777956040 @default.
- W4247875888 hasConceptScore W4247875888C2778078955 @default.
- W4247875888 hasConceptScore W4247875888C2779131090 @default.
- W4247875888 hasConceptScore W4247875888C2780091579 @default.
- W4247875888 hasConceptScore W4247875888C2780664492 @default.
- W4247875888 hasConceptScore W4247875888C540031477 @default.
- W4247875888 hasConceptScore W4247875888C54355233 @default.
- W4247875888 hasConceptScore W4247875888C55493867 @default.
- W4247875888 hasConceptScore W4247875888C71924100 @default.
- W4247875888 hasConceptScore W4247875888C7836513 @default.
- W4247875888 hasConceptScore W4247875888C79879829 @default.
- W4247875888 hasConceptScore W4247875888C81885089 @default.
- W4247875888 hasConceptScore W4247875888C86803240 @default.
- W4247875888 hasIssue "1" @default.
- W4247875888 hasLocation W42478758881 @default.
- W4247875888 hasOpenAccess W4247875888 @default.
- W4247875888 hasPrimaryLocation W42478758881 @default.
- W4247875888 hasRelatedWork W1967876710 @default.
- W4247875888 hasRelatedWork W1983323940 @default.
- W4247875888 hasRelatedWork W2009676263 @default.
- W4247875888 hasRelatedWork W2033246888 @default.
- W4247875888 hasRelatedWork W2039123883 @default.
- W4247875888 hasRelatedWork W2076320501 @default.
- W4247875888 hasRelatedWork W2083118160 @default.
- W4247875888 hasRelatedWork W2091597606 @default.
- W4247875888 hasRelatedWork W2143424242 @default.
- W4247875888 hasRelatedWork W1810219105 @default.
- W4247875888 hasVolume "70" @default.
- W4247875888 isParatext "false" @default.
- W4247875888 isRetracted "false" @default.
- W4247875888 workType "article" @default.