Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247884993> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4247884993 abstract "Abstract Molecular chaperones, including Hsp70/Hsp40 families, play central roles in binding substrates to prevent their aggregation. How Hsp40s select different conformations of substrates remains poorly understood. Here, we report a novel interaction between the Hsp40 DnaJC7 and tau that efficiently suppresses tau aggregation in vitro and in cells. DnaJC7 binds preferentially to natively folded wild-type tau, but disease-associated mutants in tau reduce chaperone binding affinity. We identify that DnaJC7 uses a single TPR domain to recognize a β-turn element in tau that contains the 275VQIINK280 amyloid motif. Wild-type tau β-turn fragments, but not mutant fragments, can block full-length tau binding to DnaJC7. These data suggest DnaJC7 preferentially binds and stabilizes natively folded conformations of tau to prevent tau conversion into amyloids. This identifies a novel mechanism of tau aggregation regulation that can be exploited as both a diagnostic and a therapeutic intervention." @default.
- W4247884993 created "2022-05-12" @default.
- W4247884993 creator A5001657894 @default.
- W4247884993 creator A5022988783 @default.
- W4247884993 creator A5025605315 @default.
- W4247884993 creator A5042673881 @default.
- W4247884993 creator A5045323031 @default.
- W4247884993 creator A5058103978 @default.
- W4247884993 creator A5069731625 @default.
- W4247884993 creator A5076273713 @default.
- W4247884993 date "2021-01-04" @default.
- W4247884993 modified "2023-10-17" @default.
- W4247884993 title "DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation" @default.
- W4247884993 doi "https://doi.org/10.21203/rs.3.rs-129204/v1" @default.
- W4247884993 hasPublicationYear "2021" @default.
- W4247884993 type Work @default.
- W4247884993 citedByCount "0" @default.
- W4247884993 crossrefType "posted-content" @default.
- W4247884993 hasAuthorship W4247884993A5001657894 @default.
- W4247884993 hasAuthorship W4247884993A5022988783 @default.
- W4247884993 hasAuthorship W4247884993A5025605315 @default.
- W4247884993 hasAuthorship W4247884993A5042673881 @default.
- W4247884993 hasAuthorship W4247884993A5045323031 @default.
- W4247884993 hasAuthorship W4247884993A5058103978 @default.
- W4247884993 hasAuthorship W4247884993A5069731625 @default.
- W4247884993 hasAuthorship W4247884993A5076273713 @default.
- W4247884993 hasBestOaLocation W42478849931 @default.
- W4247884993 hasConcept C104317684 @default.
- W4247884993 hasConcept C107824862 @default.
- W4247884993 hasConcept C12554922 @default.
- W4247884993 hasConcept C142724271 @default.
- W4247884993 hasConcept C143065580 @default.
- W4247884993 hasConcept C179104552 @default.
- W4247884993 hasConcept C185592680 @default.
- W4247884993 hasConcept C202751555 @default.
- W4247884993 hasConcept C2775962898 @default.
- W4247884993 hasConcept C2777633098 @default.
- W4247884993 hasConcept C2778670691 @default.
- W4247884993 hasConcept C2779134260 @default.
- W4247884993 hasConcept C2779281246 @default.
- W4247884993 hasConcept C502032728 @default.
- W4247884993 hasConcept C55493867 @default.
- W4247884993 hasConcept C70721500 @default.
- W4247884993 hasConcept C71924100 @default.
- W4247884993 hasConcept C86803240 @default.
- W4247884993 hasConcept C95444343 @default.
- W4247884993 hasConceptScore W4247884993C104317684 @default.
- W4247884993 hasConceptScore W4247884993C107824862 @default.
- W4247884993 hasConceptScore W4247884993C12554922 @default.
- W4247884993 hasConceptScore W4247884993C142724271 @default.
- W4247884993 hasConceptScore W4247884993C143065580 @default.
- W4247884993 hasConceptScore W4247884993C179104552 @default.
- W4247884993 hasConceptScore W4247884993C185592680 @default.
- W4247884993 hasConceptScore W4247884993C202751555 @default.
- W4247884993 hasConceptScore W4247884993C2775962898 @default.
- W4247884993 hasConceptScore W4247884993C2777633098 @default.
- W4247884993 hasConceptScore W4247884993C2778670691 @default.
- W4247884993 hasConceptScore W4247884993C2779134260 @default.
- W4247884993 hasConceptScore W4247884993C2779281246 @default.
- W4247884993 hasConceptScore W4247884993C502032728 @default.
- W4247884993 hasConceptScore W4247884993C55493867 @default.
- W4247884993 hasConceptScore W4247884993C70721500 @default.
- W4247884993 hasConceptScore W4247884993C71924100 @default.
- W4247884993 hasConceptScore W4247884993C86803240 @default.
- W4247884993 hasConceptScore W4247884993C95444343 @default.
- W4247884993 hasLocation W42478849931 @default.
- W4247884993 hasLocation W42478849932 @default.
- W4247884993 hasLocation W42478849933 @default.
- W4247884993 hasLocation W42478849934 @default.
- W4247884993 hasOpenAccess W4247884993 @default.
- W4247884993 hasPrimaryLocation W42478849931 @default.
- W4247884993 hasRelatedWork W1988252068 @default.
- W4247884993 hasRelatedWork W1998269242 @default.
- W4247884993 hasRelatedWork W2051109393 @default.
- W4247884993 hasRelatedWork W2053402937 @default.
- W4247884993 hasRelatedWork W2071845315 @default.
- W4247884993 hasRelatedWork W2171867218 @default.
- W4247884993 hasRelatedWork W2964674706 @default.
- W4247884993 hasRelatedWork W3201356533 @default.
- W4247884993 hasRelatedWork W4294550630 @default.
- W4247884993 hasRelatedWork W4327761939 @default.
- W4247884993 isParatext "false" @default.
- W4247884993 isRetracted "false" @default.
- W4247884993 workType "article" @default.