FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247897492> ?p ?o ?g. }

• W4247897492 abstract "Abstract Background Risk of stroke-related morbidity and mortality increases significantly with age. Aging is associated with chronic, low-grade inflammation, which is thought to contribute to the poorer outcomes after stroke seen in the elderly. Histamine (HA) is a major molecular mediator of inflammation and mast cells residing in the gut are a primary source of histamine. Methods Stroke was induced in male C57BL/6J mice at 3 months (young) and 20 months (aged) of age. Role of histamine after stroke was examined using young (Yg) and aged (Ag) mice, mice underwent MCAO surgery and were euthanized at 6h, 24h and 7 days post-ischemia; sham mice received the same surgery but no MCAO. In this work, we evaluated whether worsened outcomes after experimental stroke in aged mice was associated with age-related changes in mast cells, histamine levels, and histamine receptor expression in the gut, brain, and plasma. Results We found increased numbers of mast cells in the gut and the brain with aging. Using the middle cerebral artery occlusion (MCAO) model of ischemic stroke, we demonstrate that stroke leads to increased numbers of mast cells and histamine receptors in the gut. These gut-centric changes are associated with elevated levels of HA and other pro-inflammatory cytokines including IL-6, G-CSF, TNF-α, and IFN-γ in the peripheral circulation. Our data also shows that post-stroke gut inflammation led to a significant reduction of mucin-producing goblet cells and a loss of gut barrier integrity. Lastly, gut inflammation after stroke is associated with changes in the composition of the gut microbiota as early as 24 hours post-stroke. Conclusion An important theme emerging from our results is that acute inflammatory events following ischemic insults in the brain persist longer in the aged mice when compared to younger animals. Taken together, our findings implicate mast cell activation and histamine signaling as a part of peripheral inflammatory response after ischemic stroke, which are profound in aged animals. Interfering with histamine signaling orally might provide translational value to improve stroke outcome." @default.
• W4247897492 created "2022-05-12" @default.
• W4247897492 creator A5000307500 @default.
• W4247897492 creator A5000414426 @default.
• W4247897492 creator A5006299196 @default.
• W4247897492 creator A5008791837 @default.
• W4247897492 creator A5024050933 @default.
• W4247897492 creator A5030302551 @default.
• W4247897492 creator A5035455397 @default.
• W4247897492 creator A5037355596 @default.
• W4247897492 creator A5042973944 @default.
• W4247897492 creator A5046974353 @default.
• W4247897492 creator A5058580987 @default.
• W4247897492 creator A5064267882 @default.
• W4247897492 creator A5072518517 @default.
• W4247897492 creator A5074818020 @default.
• W4247897492 creator A5075276297 @default.
• W4247897492 creator A5079395552 @default.
• W4247897492 date "2020-01-23" @default.
• W4247897492 modified "2023-10-18" @default.
• W4247897492 title "Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation" @default.
• W4247897492 doi "https://doi.org/10.21203/rs.2.21718/v1" @default.
• W4247897492 hasPublicationYear "2020" @default.
• W4247897492 type Work @default.
• W4247897492 citedByCount "0" @default.
• W4247897492 crossrefType "posted-content" @default.
• W4247897492 hasAuthorship W4247897492A5000307500 @default.
• W4247897492 hasAuthorship W4247897492A5000414426 @default.
• W4247897492 hasAuthorship W4247897492A5006299196 @default.
• W4247897492 hasAuthorship W4247897492A5008791837 @default.
• W4247897492 hasAuthorship W4247897492A5024050933 @default.
• W4247897492 hasAuthorship W4247897492A5030302551 @default.
• W4247897492 hasAuthorship W4247897492A5035455397 @default.
• W4247897492 hasAuthorship W4247897492A5037355596 @default.
• W4247897492 hasAuthorship W4247897492A5042973944 @default.
• W4247897492 hasAuthorship W4247897492A5046974353 @default.
• W4247897492 hasAuthorship W4247897492A5058580987 @default.
• W4247897492 hasAuthorship W4247897492A5064267882 @default.
• W4247897492 hasAuthorship W4247897492A5072518517 @default.
• W4247897492 hasAuthorship W4247897492A5074818020 @default.
• W4247897492 hasAuthorship W4247897492A5075276297 @default.
• W4247897492 hasAuthorship W4247897492A5079395552 @default.
• W4247897492 hasBestOaLocation W42478974921 @default.
• W4247897492 hasConcept C1122143 @default.
• W4247897492 hasConcept C126322002 @default.
• W4247897492 hasConcept C127413603 @default.
• W4247897492 hasConcept C134018914 @default.
• W4247897492 hasConcept C159545944 @default.
• W4247897492 hasConcept C170493617 @default.
• W4247897492 hasConcept C203014093 @default.
• W4247897492 hasConcept C2776885963 @default.
• W4247897492 hasConcept C2776914184 @default.
• W4247897492 hasConcept C2779726688 @default.
• W4247897492 hasConcept C2780645631 @default.
• W4247897492 hasConcept C71924100 @default.
• W4247897492 hasConcept C78519656 @default.
• W4247897492 hasConceptScore W4247897492C1122143 @default.
• W4247897492 hasConceptScore W4247897492C126322002 @default.
• W4247897492 hasConceptScore W4247897492C127413603 @default.
• W4247897492 hasConceptScore W4247897492C134018914 @default.
• W4247897492 hasConceptScore W4247897492C159545944 @default.
• W4247897492 hasConceptScore W4247897492C170493617 @default.
• W4247897492 hasConceptScore W4247897492C203014093 @default.
• W4247897492 hasConceptScore W4247897492C2776885963 @default.
• W4247897492 hasConceptScore W4247897492C2776914184 @default.
• W4247897492 hasConceptScore W4247897492C2779726688 @default.
• W4247897492 hasConceptScore W4247897492C2780645631 @default.
• W4247897492 hasConceptScore W4247897492C71924100 @default.
• W4247897492 hasConceptScore W4247897492C78519656 @default.
• W4247897492 hasLocation W42478974921 @default.
• W4247897492 hasLocation W42478974922 @default.
• W4247897492 hasOpenAccess W4247897492 @default.
• W4247897492 hasPrimaryLocation W42478974921 @default.
• W4247897492 hasRelatedWork W10012610 @default.
• W4247897492 hasRelatedWork W10583791 @default.
• W4247897492 hasRelatedWork W11152845 @default.
• W4247897492 hasRelatedWork W14100651 @default.
• W4247897492 hasRelatedWork W15903579 @default.
• W4247897492 hasRelatedWork W16418346 @default.
• W4247897492 hasRelatedWork W17212509 @default.
• W4247897492 hasRelatedWork W1906851 @default.
• W4247897492 hasRelatedWork W12900382 @default.
• W4247897492 hasRelatedWork W19157625 @default.
• W4247897492 isParatext "false" @default.
• W4247897492 isRetracted "false" @default.
• W4247897492 workType "article" @default.