Matches in SemOpenAlex for { <https://semopenalex.org/work/W4247934508> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4247934508 abstract "Abstract Background The highly pathogenic Influenza H7N9 virus is believed to cause multiple organ infections. However, there have been few systematic animal experiments demonstrating the virus distribution after H7N9 virus infection. The present study was carried out to investigate the viral distribution and pathological changes in the main organs of mice after experimental infection with highly pathogenic H7N9 virus. Methods Infection of mice with A/Guangdong/GZ8H002/2017(H7N9) virus was achieved via nasal inoculation. Mice were killed at 2, 3, and 7 days post infection. The other mice were used to observe their illness status and weight changes. Reverse transcription polymerase chain reaction and viral isolation were used to analyse the characteristics of viral invasion. The pathological changes of the main organs were observed using haematoxylin and eosin staining and immunohistochemistry. Results The weight of H7N9 virus-infected mice increased slightly in the first two days. However, the weight of the mice decreased sharply in the following days, by up to 20%. All the mice had died by the 8th day post infection and showed multiple organ injury. The emergence of viremia in mice was synchronous with lung infection. On the third day post infection, except in the brain, the virus could be isolated from all organs (lung, heart, kidney, liver, and spleen). On the seventh day post infection, the virus could be detected in all six organs. Brain infection was detected in all mice, and the viral titre in the heart, kidney, and spleen infection was high. Conclusion Acute diffuse lung injury was the initial pathogenesis in highly pathogenic H7N9 virus infection. In addition to lung infection and viremia, the highly pathogenic H7N9 virus could cause multiple organ infection and injury." @default.
- W4247934508 created "2022-05-12" @default.
- W4247934508 creator A5016364911 @default.
- W4247934508 creator A5017933096 @default.
- W4247934508 creator A5021691628 @default.
- W4247934508 creator A5027734759 @default.
- W4247934508 creator A5038407883 @default.
- W4247934508 creator A5041928105 @default.
- W4247934508 creator A5057422995 @default.
- W4247934508 creator A5064001291 @default.
- W4247934508 creator A5079237764 @default.
- W4247934508 creator A5081214301 @default.
- W4247934508 date "2021-09-16" @default.
- W4247934508 modified "2023-09-23" @default.
- W4247934508 title "The viral distribution and pathological characteristics of BALB/c mice infected with highly pathogenic Influenza H7N9 virus" @default.
- W4247934508 doi "https://doi.org/10.21203/rs.3.rs-757597/v2" @default.
- W4247934508 hasPublicationYear "2021" @default.
- W4247934508 type Work @default.
- W4247934508 citedByCount "0" @default.
- W4247934508 crossrefType "posted-content" @default.
- W4247934508 hasAuthorship W4247934508A5016364911 @default.
- W4247934508 hasAuthorship W4247934508A5017933096 @default.
- W4247934508 hasAuthorship W4247934508A5021691628 @default.
- W4247934508 hasAuthorship W4247934508A5027734759 @default.
- W4247934508 hasAuthorship W4247934508A5038407883 @default.
- W4247934508 hasAuthorship W4247934508A5041928105 @default.
- W4247934508 hasAuthorship W4247934508A5057422995 @default.
- W4247934508 hasAuthorship W4247934508A5064001291 @default.
- W4247934508 hasAuthorship W4247934508A5079237764 @default.
- W4247934508 hasAuthorship W4247934508A5081214301 @default.
- W4247934508 hasBestOaLocation W42479345081 @default.
- W4247934508 hasConcept C126322002 @default.
- W4247934508 hasConcept C134018914 @default.
- W4247934508 hasConcept C142462285 @default.
- W4247934508 hasConcept C142724271 @default.
- W4247934508 hasConcept C159047783 @default.
- W4247934508 hasConcept C203014093 @default.
- W4247934508 hasConcept C2522874641 @default.
- W4247934508 hasConcept C2776185481 @default.
- W4247934508 hasConcept C2777546802 @default.
- W4247934508 hasConcept C2777714996 @default.
- W4247934508 hasConcept C2780091579 @default.
- W4247934508 hasConcept C2780931953 @default.
- W4247934508 hasConcept C71924100 @default.
- W4247934508 hasConcept C86803240 @default.
- W4247934508 hasConceptScore W4247934508C126322002 @default.
- W4247934508 hasConceptScore W4247934508C134018914 @default.
- W4247934508 hasConceptScore W4247934508C142462285 @default.
- W4247934508 hasConceptScore W4247934508C142724271 @default.
- W4247934508 hasConceptScore W4247934508C159047783 @default.
- W4247934508 hasConceptScore W4247934508C203014093 @default.
- W4247934508 hasConceptScore W4247934508C2522874641 @default.
- W4247934508 hasConceptScore W4247934508C2776185481 @default.
- W4247934508 hasConceptScore W4247934508C2777546802 @default.
- W4247934508 hasConceptScore W4247934508C2777714996 @default.
- W4247934508 hasConceptScore W4247934508C2780091579 @default.
- W4247934508 hasConceptScore W4247934508C2780931953 @default.
- W4247934508 hasConceptScore W4247934508C71924100 @default.
- W4247934508 hasConceptScore W4247934508C86803240 @default.
- W4247934508 hasLocation W42479345081 @default.
- W4247934508 hasLocation W42479345082 @default.
- W4247934508 hasOpenAccess W4247934508 @default.
- W4247934508 hasPrimaryLocation W42479345081 @default.
- W4247934508 hasRelatedWork W1487857142 @default.
- W4247934508 hasRelatedWork W1970525466 @default.
- W4247934508 hasRelatedWork W2032469389 @default.
- W4247934508 hasRelatedWork W2057745002 @default.
- W4247934508 hasRelatedWork W2071491616 @default.
- W4247934508 hasRelatedWork W2082080978 @default.
- W4247934508 hasRelatedWork W2150845218 @default.
- W4247934508 hasRelatedWork W2155048514 @default.
- W4247934508 hasRelatedWork W3024240219 @default.
- W4247934508 hasRelatedWork W2411483263 @default.
- W4247934508 isParatext "false" @default.
- W4247934508 isRetracted "false" @default.
- W4247934508 workType "article" @default.