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- W4247980911 abstract "Protein phosphatase-2A (PP2A) activity is significantly suppressed in Alzheimer’s disease. We have reported that glycogen synthase kinase-3β (GSK-3β) inhibits PP2A via upregulating the phosphorylation of PP2A catalytic subunit (PP2AC). Here we studied the effects of GSK-3β on the inhibitory demethylation of PP2A at leucine-309 (dmL309-PP2AC). We found that GSK-3β regulates dmL309-PP2AC level by regulating PME-1 and PPMT1. Knockdown of PME-1 or PPMT1 eliminated the effects of GSK-3β on PP2AC. GSK-3 could negatively regulate PP2A regulatory subunit protein level. We conclude that GSK-3β can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1." @default.
- W4247980911 created "2022-05-12" @default.
- W4247980911 date "2016-01-01" @default.
- W4247980911 modified "2023-09-25" @default.
- W4247980911 title "Inflammation increase the invasive ability of pancreatic cancer cells by inhibiting the expression of protein phosphatase 2A catalytic subunit" @default.
- W4247980911 doi "https://doi.org/10.1016/j.pan.2015.12.146" @default.
- W4247980911 hasPublicationYear "2016" @default.
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