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- W4247990190 abstract "<h3>In Reply.—</h3> The comments by Dr Moskovitz are appreciated and deserve further explanation. We recognize that new antimicrobials with relatively long half-lives (eg, cefonicid, ceforanide, and ceftriaxone) have been shown to be effective when used prophylactically in single preoperative doses; however, the literature supports the older and less expensive, first-generation cephalosporins (eg, cefazolin) as being effective for prophylaxis when administered in single preoperative doses. Traditionally, older cephalosporins have been studied for surgical prophylaxis using regimens where two to 20 postoperative doses were provided in addition to a preoperative dose.<sup>1</sup>Where these agents have been studied using only single preoperative doses, they have been found effective.<sup>1</sup>Multidose regimens are not, therefore, generally necessary. For example, Lewis et al<sup>2</sup>reported recently that a single preoperative dose of cefazolin is effective in decreasing postoperative infection rate in high-risk biliary surgery. Our own investigations have demonstrated that cefazolin produces adequate intraoperative" @default.
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- W4247990190 date "1985-06-21" @default.
- W4247990190 modified "2023-09-26" @default.
- W4247990190 title "The prophylactic use of cephalosporins for surgery" @default.
- W4247990190 doi "https://doi.org/10.1001/jama.253.23.3399" @default.
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