Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248004920> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4248004920 endingPage "64" @default.
- W4248004920 startingPage "61" @default.
- W4248004920 abstract "Peripheral administration of interleukin-1 (IL-1) has been shown to activate induction of Fos in the brain, but the mechanism is not known. Because cerebral noradrenergic systems have been implicated in Fos induction, we studied the IL-1-induced appearance of Fos in mice pretreated with 6-hydroxydopamine (6-OHDA) which depleted cerebral norepinephrine (NE) by more than 90%, but did not significantly alter dopamine. Intraperitoneally injected IL-1β increased Fos in several brain regions, but most obviously in the hypothalamic paraventricular nucleus (PVN). Pretreatment with 6-OHDA substantially reduced the IL-1-induced Fos increase in the PVN which was no longer statistically significant. When the 6-OHDA treatment was preceded by administration of desmethylimipramine which prevents NE depletion, IL-1 treatment increased Fos in the PVN, suggesting that the effect of 6-OHDA was indeed related to the depletion of NE. These results suggest that the noradrenergic innervation of the PVN is involved in the IL-1-induced induction of Fos in the PVN. By contrast with previous experiments in rats, the IL-1-induced increase in plasma corticosterone was not significantly altered by the 6-OHDA pretreatment in mice." @default.
- W4248004920 created "2022-05-12" @default.
- W4248004920 creator A5015094482 @default.
- W4248004920 date "1996-12-01" @default.
- W4248004920 modified "2023-09-25" @default.
- W4248004920 title "The Role of Cerebral Noradrenergic Systems in the Fos Response to Interleukin-1" @default.
- W4248004920 doi "https://doi.org/10.1016/s0361-9230(96)00173-6" @default.
- W4248004920 hasPublicationYear "1996" @default.
- W4248004920 type Work @default.
- W4248004920 citedByCount "0" @default.
- W4248004920 crossrefType "journal-article" @default.
- W4248004920 hasAuthorship W4248004920A5015094482 @default.
- W4248004920 hasConcept C104317684 @default.
- W4248004920 hasConcept C126322002 @default.
- W4248004920 hasConcept C134018914 @default.
- W4248004920 hasConcept C137183658 @default.
- W4248004920 hasConcept C150194340 @default.
- W4248004920 hasConcept C185592680 @default.
- W4248004920 hasConcept C2777003273 @default.
- W4248004920 hasConcept C2777288102 @default.
- W4248004920 hasConcept C2778514916 @default.
- W4248004920 hasConcept C2780323455 @default.
- W4248004920 hasConcept C2780352252 @default.
- W4248004920 hasConcept C2780938664 @default.
- W4248004920 hasConcept C2911016594 @default.
- W4248004920 hasConcept C513476851 @default.
- W4248004920 hasConcept C55493867 @default.
- W4248004920 hasConcept C71315377 @default.
- W4248004920 hasConcept C71924100 @default.
- W4248004920 hasConceptScore W4248004920C104317684 @default.
- W4248004920 hasConceptScore W4248004920C126322002 @default.
- W4248004920 hasConceptScore W4248004920C134018914 @default.
- W4248004920 hasConceptScore W4248004920C137183658 @default.
- W4248004920 hasConceptScore W4248004920C150194340 @default.
- W4248004920 hasConceptScore W4248004920C185592680 @default.
- W4248004920 hasConceptScore W4248004920C2777003273 @default.
- W4248004920 hasConceptScore W4248004920C2777288102 @default.
- W4248004920 hasConceptScore W4248004920C2778514916 @default.
- W4248004920 hasConceptScore W4248004920C2780323455 @default.
- W4248004920 hasConceptScore W4248004920C2780352252 @default.
- W4248004920 hasConceptScore W4248004920C2780938664 @default.
- W4248004920 hasConceptScore W4248004920C2911016594 @default.
- W4248004920 hasConceptScore W4248004920C513476851 @default.
- W4248004920 hasConceptScore W4248004920C55493867 @default.
- W4248004920 hasConceptScore W4248004920C71315377 @default.
- W4248004920 hasConceptScore W4248004920C71924100 @default.
- W4248004920 hasIssue "1" @default.
- W4248004920 hasLocation W42480049201 @default.
- W4248004920 hasOpenAccess W4248004920 @default.
- W4248004920 hasPrimaryLocation W42480049201 @default.
- W4248004920 hasRelatedWork W1013197 @default.
- W4248004920 hasRelatedWork W11980125 @default.
- W4248004920 hasRelatedWork W12222479 @default.
- W4248004920 hasRelatedWork W16267566 @default.
- W4248004920 hasRelatedWork W25293670 @default.
- W4248004920 hasRelatedWork W26758668 @default.
- W4248004920 hasRelatedWork W32970357 @default.
- W4248004920 hasRelatedWork W419743 @default.
- W4248004920 hasRelatedWork W4286999 @default.
- W4248004920 hasRelatedWork W516588 @default.
- W4248004920 hasVolume "41" @default.
- W4248004920 isParatext "false" @default.
- W4248004920 isRetracted "false" @default.
- W4248004920 workType "article" @default.