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- W4248098105 abstract "(Cancer Cell 18, 207-219; September 14, 2010) It has come to our attention that an error was made in the final assembly of Figures 7A and 7B . While the figure legends and data labels for the two graphs were correct, the graphs themselves were transposed. We have now corrected this error in the revised Figures 7A and 7B, printed below. This oversight has no bearing on the conclusions reached in this study and we apologize for any confusion caused by the transposed graphs. Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic TransformationWang et al.Cancer CellSeptember 14, 2010In BriefRho GTPases impact a number of activities important for oncogenesis. We describe a small molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human breast cancer and B lymphoma cells, without affecting normal cells. We identify the target of this inhibitor to be the metabolic enzyme glutaminase, which catalyzes the hydrolysis of glutamine to glutamate. We show that transformed fibroblasts and breast cancer cells exhibit elevated glutaminase activity that is dependent on Rho GTPases and NF-κB activity, and is blocked by the small molecule inhibitor. Full-Text PDF Open Archive" @default.
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- W4248098105 date "2010-10-01" @default.
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- W4248098105 title "Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation" @default.
- W4248098105 doi "https://doi.org/10.1016/j.ccr.2010.10.011" @default.
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