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- W4248121626 abstract "This chapter explores practical considerations in the use of response-adaptive randomization. Because response-adaptive randomization procedures are randomized, they enjoy many of the same benefits of other randomization procedures in terms of mitigation of bias. However, there are several ways that bias can enter a trial using response-adaptive randomization procedures. Response-adaptive randomization procedures require more work to implement, in that the randomization procedure must be programmed and the program must update the allocation probabilities after each patient response. The authors recommend that extensive simulations be run to ascertain the operating characteristics of the procedure, to determine sample size requirements, and to assess the potential benefits of using response-adaptive randomization. The fluoxetine trial is an example of a well-conducted and thoughtfully designed clinical trial. Rosenberger (1999) discusses conditions under which the use of response-adaptive randomization is reasonable." @default.
- W4248121626 created "2022-05-12" @default.
- W4248121626 date "2015-10-30" @default.
- W4248121626 modified "2023-10-14" @default.
- W4248121626 title "Response‐Adaptive Randomization in Practice" @default.
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- W4248121626 doi "https://doi.org/10.1002/9781118742112.ch12" @default.
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