Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248127994> ?p ?o ?g. }
- W4248127994 endingPage "1253" @default.
- W4248127994 startingPage "1237" @default.
- W4248127994 abstract "Introduction: This is a combined analysis of therapeutic drug monitoring (TDM) studies of long-acting injectable paliperidone formulations: monthly (PP1M) and three-month (PP3M) injections.Areas covered: Fourteen PP1M articles and one PP3M article were identified. Using the paliperidone concentration/dose (C/D) ratio as a measure of clearance provided a weighted mean of 7.7 ng/ml per mg/day among 69 patients from three steady-state PP1M studies (twice as high as oral paliperidone). C/D ratios were: 1) higher by a factor of 1.26 in 12 geriatric patients, 2) lower in obese patients, and 3) 50% lower in three patients taking carbamazepine. No clinically meaningful PP3M pharmacokinetic data have been published.Expert commentary: Half-life studies and more TDM PP1M studies using steady state are urgently needed. Early TDM studies may help orient PP1M dosing but steady state may not be reached until after the ninth injection (8 months). PP3M may take > 1 year to reach steady state. Any clinician considering switching patients to PP1M: 1) should switch from oral risperidone to PP1M rather than from oral paliperidone to PP1M, and 2) become proficient in paliperidone TDM to use during switches. TDM is highly recommended for patients with abnormal clearance (from obesity, geriatric age, or potent inducers)." @default.
- W4248127994 created "2022-05-12" @default.
- W4248127994 creator A5007740742 @default.
- W4248127994 creator A5056735832 @default.
- W4248127994 creator A5056973211 @default.
- W4248127994 creator A5071320525 @default.
- W4248127994 date "2018-12-02" @default.
- W4248127994 modified "2023-09-27" @default.
- W4248127994 title "A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting paliperidone" @default.
- W4248127994 cites W1490484843 @default.
- W4248127994 cites W1600870989 @default.
- W4248127994 cites W1840586683 @default.
- W4248127994 cites W1906145619 @default.
- W4248127994 cites W1931239046 @default.
- W4248127994 cites W1953157543 @default.
- W4248127994 cites W1953171524 @default.
- W4248127994 cites W1954706707 @default.
- W4248127994 cites W1969277923 @default.
- W4248127994 cites W1979118079 @default.
- W4248127994 cites W1979700184 @default.
- W4248127994 cites W1986373093 @default.
- W4248127994 cites W1992181956 @default.
- W4248127994 cites W1994462863 @default.
- W4248127994 cites W1994870822 @default.
- W4248127994 cites W2005630045 @default.
- W4248127994 cites W2008430084 @default.
- W4248127994 cites W2009832071 @default.
- W4248127994 cites W2013615650 @default.
- W4248127994 cites W2017210199 @default.
- W4248127994 cites W2022592863 @default.
- W4248127994 cites W2026415776 @default.
- W4248127994 cites W2029986378 @default.
- W4248127994 cites W2033328636 @default.
- W4248127994 cites W2062358813 @default.
- W4248127994 cites W2064792616 @default.
- W4248127994 cites W2068128033 @default.
- W4248127994 cites W2069799317 @default.
- W4248127994 cites W2072303299 @default.
- W4248127994 cites W2072686355 @default.
- W4248127994 cites W2080185803 @default.
- W4248127994 cites W2081135880 @default.
- W4248127994 cites W2081680186 @default.
- W4248127994 cites W2086550135 @default.
- W4248127994 cites W2086722797 @default.
- W4248127994 cites W2096271865 @default.
- W4248127994 cites W2096393984 @default.
- W4248127994 cites W2098666011 @default.
- W4248127994 cites W2100937238 @default.
- W4248127994 cites W2110079086 @default.
- W4248127994 cites W2127664594 @default.
- W4248127994 cites W2127872656 @default.
- W4248127994 cites W2130033419 @default.
- W4248127994 cites W2136924078 @default.
- W4248127994 cites W2140000974 @default.
- W4248127994 cites W2140577591 @default.
- W4248127994 cites W2147394078 @default.
- W4248127994 cites W2179769096 @default.
- W4248127994 cites W2251665514 @default.
- W4248127994 cites W2274440691 @default.
- W4248127994 cites W2287081661 @default.
- W4248127994 cites W2292129095 @default.
- W4248127994 cites W2299467284 @default.
- W4248127994 cites W2315045824 @default.
- W4248127994 cites W2320970266 @default.
- W4248127994 cites W2327059612 @default.
- W4248127994 cites W2404733575 @default.
- W4248127994 cites W2411843282 @default.
- W4248127994 cites W2417149763 @default.
- W4248127994 cites W2462441505 @default.
- W4248127994 cites W2519195288 @default.
- W4248127994 cites W2530590186 @default.
- W4248127994 cites W2592742437 @default.
- W4248127994 cites W2592878342 @default.
- W4248127994 cites W2592907911 @default.
- W4248127994 cites W2592909584 @default.
- W4248127994 cites W2592963781 @default.
- W4248127994 cites W2593757032 @default.
- W4248127994 cites W2601943217 @default.
- W4248127994 cites W2611393846 @default.
- W4248127994 cites W2611801807 @default.
- W4248127994 cites W2613505090 @default.
- W4248127994 cites W2620112462 @default.
- W4248127994 cites W2666262682 @default.
- W4248127994 cites W2718238251 @default.
- W4248127994 cites W2736194893 @default.
- W4248127994 cites W2739777237 @default.
- W4248127994 cites W2742742064 @default.
- W4248127994 cites W2751415386 @default.
- W4248127994 cites W2753966476 @default.
- W4248127994 cites W2759194023 @default.
- W4248127994 cites W2767154475 @default.
- W4248127994 cites W2769910603 @default.
- W4248127994 cites W2773206359 @default.
- W4248127994 cites W2784903423 @default.
- W4248127994 cites W2792416293 @default.
- W4248127994 cites W2792421382 @default.
- W4248127994 cites W2793428843 @default.
- W4248127994 cites W2794894288 @default.