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- W4248143357 abstract "Neuronal membrane potential depends on the distribution of ions across the plasma membrane and the permeability of the membrane to those ions afforded by transmembrane proteins. Ions cannot pass through a lipid bilayer but enter or exit neurons through ion channels. When activated by voltage or a ligand, ion channels open to form a pore through which selective ions can pass. The ion channels that support a resting membrane potential are critical to setting a cell’s excitability. From the distribution of an ionic species, the Nernst potential can be used to predict the steady-state potential for that one ion. Neurons are permeable to potassium, sodium, and chloride ions at rest. The Goldman-Hodgkin-Katz equation takes into consideration the influence of multiple ionic species and can be used to predict neuronal membrane potential. Finally, how synaptic inputs affect neurons through synaptic currents and changes in membrane resistance is described." @default.
- W4248143357 created "2022-05-12" @default.
- W4248143357 creator A5039558748 @default.
- W4248143357 date "2017-02-01" @default.
- W4248143357 modified "2023-09-27" @default.
- W4248143357 title "The Neuron at Rest" @default.
- W4248143357 doi "https://doi.org/10.1093/med/9780190237493.003.0009" @default.
- W4248143357 hasPublicationYear "2017" @default.
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