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- W4248157098 abstract "The proteasome is a large multifunctional proteolytic complex responsible for non-lysosomal protein degradation [1-3]. The form of the enzyme most frequent-ly studied is the 20S proteasome, a 700 kDa complex which catalyzes at least five proteolytic activities. The 20S proteasome is the catalytic core of the 26S proteasome, a larger particle (2000 kDa) which also contains two copies of a 19S regulatory complex. The 26S form of the proteasome catalyzes ATP-dependent hydrolysis of ubiquitinated proteins, while the 20S proteasome is not ATP-dependent. The enzyme is conserved from archaebacteria and eubacteria, which contain only the 20S proteasome, through eukaryotes, which express both 20S and 26S forms of the enzyme [4]. The proteasome is located in both the cytosol and nucleus of eukaryotic cells and is a predominant cellular component, comprising up to 1% of the total protein in most cells. The enzyme plays a major role in the degrada-tion of misfolded, damaged or abnormal proteins, as well as in the modulation of levels of key cell signaling regulators [5]. The activity of the proteasome is highly regulated, and any deregulation has the potential to lead to pathological condi-tions." @default.
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- W4248157098 date "2000-01-01" @default.
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- W4248157098 title "Proteasome inhibitors" @default.
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