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- W4248178568 abstract "Unsintered hydroxyapatite particles/poly(l-lactide) (u-HA/PLLA) composites with an initial bending strength of up to 270 MPa were developed based on the hypothesis that inclusion of u-HA particles in a PLLA matrix might enhance bone bonding. The purpose of this study was to examine the bonding strength and behavior of these u-HA/PLLA composites on the surface of the bone cortex. Composites containing 30 (u-HA30), 40 (u-HA40), or 50 wt % (u-HA50) of fine u-HA particles (3-μm average particle size) were prepared. Semicolumnar plates of these composites and control PLLA plates were fixed with metal screws to the surface of both proximal tibial cortices in 45 rabbits. The loads required to detach the plates from the bone cortex surface, defined as the bonding strengths, were measured at 4, 8, and 25 weeks after implantation. Bonding strengths in the u-HA30 group at 8 weeks and in the u-HA40 and u-HA50 groups at each postimplantation time were significantly greater than in the PLLA group (post hoc test using Fisher's protected least significant difference method). At each postimplantation time histological examinations revealed direct contact between the bone and the u-HA/PLLA composite plates without any intervening fibrous tissue. There was no evidence of any inflammatory or foreign-body response in any group throughout the follow-up periods. The results of this study suggest that the biodegradable PLLA fixation plates amended with u-HA particles could be functionally superior to PLLA plates without particles. © 1999 John Wiley & Sons, Inc. J. Biomed Mater Res, 47, 412–419, 1999." @default.
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- W4248178568 date "1999-12-05" @default.
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- W4248178568 title "Bonding behavior of ultrahigh strength unsintered hydroxyapatite particles/poly(L‐lactide) composites to surface of tibial cortex in rabbits" @default.
- W4248178568 doi "https://doi.org/10.1002/(sici)1097-4636(19991205)47:3<412::aid-jbm17>3.3.co;2-2" @default.
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