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- W4248246167 abstract "Aims and background Nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) are two major causes of liver disease worldwide. Epidemiological and clinical data have clearly demonstrated that NAFLD and its associated metabolic abnormalities are a risk factor for HCC. Traditionally, the mechanisms whereby NAFLD acts as a risk for HCC are believed to include replicative senescence of steatotic hepatocytes and compensatory hyperplasia of progenitor cells as a reaction to chronic hepatic injury. Recent years have witnessed significant advances in our understanding of the mechanisms underlying the link between NAFLD and HCC. Methods In the present review, we provide an update on the pathophysiological pathways linking NAFLD and its associated metabolic derangements to malignant hepatic transformation, with a special focus on insulin resistance, adipokines, inflammation, and angiogenesis. We will also discuss the potential therapeutic implications that such molecular links carry. Results Although treating NAFLD could reduce the risk of malignant hepatic transformation, no long-term studies focusing on this issue have been conducted thus far. Insulin resistance, inflammation as well as derangements in adipokines and angiogenic factors associated with NAFLD are closely intertwined with the risk of developing HCC. Conclusions Traditional therapeutic approaches in NAFLD including metformin and statins may theoretically reduce the risk of HCC by acting on common pathophysiological pathways shared by NAFLD and HCC." @default.
- W4248246167 created "2022-05-12" @default.
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- W4248246167 date "2013-01-01" @default.
- W4248246167 modified "2023-09-30" @default.
- W4248246167 title "Linking Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma: From Bedside to Bench and Back" @default.
- W4248246167 cites W1520575957 @default.
- W4248246167 cites W1555731388 @default.
- W4248246167 cites W1569234975 @default.
- W4248246167 cites W1604404839 @default.
- W4248246167 cites W164912637 @default.
- W4248246167 cites W1906462177 @default.
- W4248246167 cites W1964873462 @default.
- W4248246167 cites W1967749971 @default.
- W4248246167 cites W1967972402 @default.
- W4248246167 cites W1968859891 @default.
- W4248246167 cites W1975655703 @default.
- W4248246167 cites W1976226387 @default.
- W4248246167 cites W1977849864 @default.
- W4248246167 cites W1978723895 @default.
- W4248246167 cites W1984924723 @default.
- W4248246167 cites W1986252060 @default.
- W4248246167 cites W1988963232 @default.
- W4248246167 cites W1990878287 @default.
- W4248246167 cites W1992118751 @default.
- W4248246167 cites W2002046476 @default.
- W4248246167 cites W2003423939 @default.
- W4248246167 cites W2003945587 @default.
- W4248246167 cites W2008567039 @default.
- W4248246167 cites W2012981773 @default.
- W4248246167 cites W2018593069 @default.
- W4248246167 cites W2019166464 @default.
- W4248246167 cites W2022053538 @default.
- W4248246167 cites W2022807068 @default.
- W4248246167 cites W2023353432 @default.
- W4248246167 cites W2030230081 @default.
- W4248246167 cites W2034674595 @default.
- W4248246167 cites W2037622600 @default.
- W4248246167 cites W2037637732 @default.
- W4248246167 cites W2038050137 @default.
- W4248246167 cites W2044344375 @default.
- W4248246167 cites W2053537671 @default.
- W4248246167 cites W2054178489 @default.
- W4248246167 cites W2056439450 @default.
- W4248246167 cites W2057679677 @default.
- W4248246167 cites W2059643846 @default.
- W4248246167 cites W2062961142 @default.
- W4248246167 cites W2068714011 @default.
- W4248246167 cites W2069841150 @default.
- W4248246167 cites W2070444664 @default.
- W4248246167 cites W2071143543 @default.
- W4248246167 cites W2071875898 @default.
- W4248246167 cites W2078214705 @default.
- W4248246167 cites W2085228172 @default.
- W4248246167 cites W2086431545 @default.
- W4248246167 cites W2088975057 @default.
- W4248246167 cites W2098555833 @default.
- W4248246167 cites W2100896781 @default.
- W4248246167 cites W2106844955 @default.
- W4248246167 cites W2111707331 @default.
- W4248246167 cites W2112291880 @default.
- W4248246167 cites W2116205649 @default.
- W4248246167 cites W2118278569 @default.
- W4248246167 cites W2118559345 @default.
- W4248246167 cites W2123856468 @default.
- W4248246167 cites W2124464501 @default.
- W4248246167 cites W2133926807 @default.
- W4248246167 cites W2134167042 @default.
- W4248246167 cites W2136795008 @default.
- W4248246167 cites W2138902556 @default.
- W4248246167 cites W2142052994 @default.
- W4248246167 cites W2143829302 @default.
- W4248246167 cites W2146224145 @default.
- W4248246167 cites W2148986188 @default.
- W4248246167 cites W2151106782 @default.
- W4248246167 cites W2152524374 @default.
- W4248246167 cites W2155165300 @default.
- W4248246167 cites W2155868778 @default.
- W4248246167 cites W2158696324 @default.
- W4248246167 cites W2158852128 @default.
- W4248246167 cites W2160416763 @default.
- W4248246167 cites W2163204808 @default.
- W4248246167 cites W2163382189 @default.
- W4248246167 cites W2169715697 @default.
- W4248246167 cites W2182023079 @default.
- W4248246167 cites W4245403358 @default.
- W4248246167 cites W4255769967 @default.
- W4248246167 doi "https://doi.org/10.1177/030089161309900102" @default.
- W4248246167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23548993" @default.
- W4248246167 hasPublicationYear "2013" @default.
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