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- W4248257068 abstract "Abstract BackgroundAfter enterocystoplasty, some serious complications are presented, which are resulted from the chronic interaction between urine and intestinal epithelium. Composite cystoplasty is recommended as a method of surmounting these complications by replacing intestinal epithelium with autologous peritoneum.To develop a feasible surgical procedure for composite cystoplasty which can reduce serious complications postoperatively, keep sterility by excluding the possibility of contamination from the ileal contents, and provide a basis for the further clinical application of reconstruction bladder.MethodsSix female Chinese minipigs ( CMP ) were randomly chosen, weighted 28–33 kg. By intravenous anesthesia, bladder augmentation was carried out (implanting autologus peritoneum vascularized and, de-epithelialised ileal- seromuscular flaps. The composite cystoplasty used these flaps to mend and reconstruct bladders). Upon release of catheters and balloon at the fifth day, by monitoring the voiding behaviors of the pigs, routine pathology and immunohistochemistry were done by euthanizing the pigs at the 12th week.ResultsSix pigs experienced reconstruction, without complications. Ileum was 10 cm long, and the area of substitute peritoneum was 7 × 4 cm 2 . Voiding behavior was normal, and urine was clear in all animals after the catheter was taken out. Autopsy indicated that the fixed, bladder was in good condition, covered by continuous urothelium while the peritoneum disappeared, without regeneration of calculi, mucus, fibrosis, or ileal mucosa. Pathological examination demonstrated the success of the technique in developing the seromuscular flap without epithelial remnant. Bladders augmented with autologous peritoneum had fewer lymphocytes infiltration, indicating more effective urinary barrier function.Conclusion In this experimental porcine model, reconstruction bladder by autologous peritoneum and ileal seromuscular segment is an ideal approach since it can prevent regrowth of ileal epithelial cells and avoid the complications of conventional enterocystoplasty. The potential functions of the peritoneum are both protection and transitional support. This animal study provides a basis for further clinical application of the new enterocysplasty." @default.
- W4248257068 created "2022-05-12" @default.
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- W4248257068 date "2020-05-22" @default.
- W4248257068 modified "2023-09-30" @default.
- W4248257068 title "Cystoplasty Combined Autologous Peritoneum with Ileal Seromuscular segment: a new model study" @default.
- W4248257068 doi "https://doi.org/10.21203/rs.3.rs-27513/v1" @default.
- W4248257068 hasPublicationYear "2020" @default.
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