Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248285425> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4248285425 abstract "OBJECTIVE: The general consensus has been that estrogen is invariably a risk factor for ischemic stroke (IS). We reviewed new observational studies that challenge this simple conclusion.METHODS: This was a review of observational studies of the association of premature or early menopause with stroke or IS published in English from 2006 through 2010.RESULTS: Three cohort studies showed an increased risk of all types of stroke in women who underwent bilateral oophorectomy compared with women who conserved their ovaries before age 50 years. The increased risk of stroke was reduced by hormone therapy in one of the studies, suggesting that estrogen deprivation is involved in the association. Four additional observational studies showed an association of all types of stroke or IS with the early onset of menopause or with a shorter life span of ovarian activity. In three of the seven studies, the association was restricted to IS. Age at menopause was more important than type of menopause (natural vs induced).CONCLUSIONS: The findings from seven recent observational studies challenge the consensus that estrogen is invariably a risk factor for IS and can be reconciled by a unifying timing hypothesis. We hypothesize that estrogen is protective for IS before age 50 years and may become a risk factor for IS after age 50 years or, possibly, after age 60 years. These findings are relevant to women who experienced premature or early menopause or to women considering prophylactic bilateral oophorectomy before the onset of natural menopause. PMID: 21993082 Funding information This work was supported by: NIA NIH HHS, United States Grant ID: R01 AG034676-45 NINDS NIH HHS, United States Grant ID: R01 NS033978 NINDS NIH HHS, United States Grant ID: NS 033978 NINDS NIH HHS, United States Grant ID: R01 NS033978-10 NIA NIH HHS, United States Grant ID: R01 AG034676 NIA NIH HHS, United States Grant ID: AG 034676 More Less keyboard_arrow_down" @default.
- W4248285425 created "2022-05-12" @default.
- W4248285425 creator A5028122459 @default.
- W4248285425 date "2011-10-20" @default.
- W4248285425 modified "2023-10-16" @default.
- W4248285425 title "Faculty Opinions recommendation of Premature menopause or early menopause and risk of ischemic stroke." @default.
- W4248285425 doi "https://doi.org/10.3410/f.13357012.14726285" @default.
- W4248285425 hasPublicationYear "2011" @default.
- W4248285425 type Work @default.
- W4248285425 citedByCount "0" @default.
- W4248285425 crossrefType "dataset" @default.
- W4248285425 hasAuthorship W4248285425A5028122459 @default.
- W4248285425 hasBestOaLocation W42482854251 @default.
- W4248285425 hasConcept C107130276 @default.
- W4248285425 hasConcept C126322002 @default.
- W4248285425 hasConcept C127413603 @default.
- W4248285425 hasConcept C141071460 @default.
- W4248285425 hasConcept C187212893 @default.
- W4248285425 hasConcept C201903717 @default.
- W4248285425 hasConcept C23131810 @default.
- W4248285425 hasConcept C2777164284 @default.
- W4248285425 hasConcept C2777696064 @default.
- W4248285425 hasConcept C2778562196 @default.
- W4248285425 hasConcept C2779494336 @default.
- W4248285425 hasConcept C2780645631 @default.
- W4248285425 hasConcept C2910557164 @default.
- W4248285425 hasConcept C29456083 @default.
- W4248285425 hasConcept C50440223 @default.
- W4248285425 hasConcept C71924100 @default.
- W4248285425 hasConcept C72563966 @default.
- W4248285425 hasConcept C78519656 @default.
- W4248285425 hasConceptScore W4248285425C107130276 @default.
- W4248285425 hasConceptScore W4248285425C126322002 @default.
- W4248285425 hasConceptScore W4248285425C127413603 @default.
- W4248285425 hasConceptScore W4248285425C141071460 @default.
- W4248285425 hasConceptScore W4248285425C187212893 @default.
- W4248285425 hasConceptScore W4248285425C201903717 @default.
- W4248285425 hasConceptScore W4248285425C23131810 @default.
- W4248285425 hasConceptScore W4248285425C2777164284 @default.
- W4248285425 hasConceptScore W4248285425C2777696064 @default.
- W4248285425 hasConceptScore W4248285425C2778562196 @default.
- W4248285425 hasConceptScore W4248285425C2779494336 @default.
- W4248285425 hasConceptScore W4248285425C2780645631 @default.
- W4248285425 hasConceptScore W4248285425C2910557164 @default.
- W4248285425 hasConceptScore W4248285425C29456083 @default.
- W4248285425 hasConceptScore W4248285425C50440223 @default.
- W4248285425 hasConceptScore W4248285425C71924100 @default.
- W4248285425 hasConceptScore W4248285425C72563966 @default.
- W4248285425 hasConceptScore W4248285425C78519656 @default.
- W4248285425 hasLocation W42482854251 @default.
- W4248285425 hasOpenAccess W4248285425 @default.
- W4248285425 hasPrimaryLocation W42482854251 @default.
- W4248285425 hasRelatedWork W189566381 @default.
- W4248285425 hasRelatedWork W1973480759 @default.
- W4248285425 hasRelatedWork W2016373832 @default.
- W4248285425 hasRelatedWork W2030997633 @default.
- W4248285425 hasRelatedWork W2046428578 @default.
- W4248285425 hasRelatedWork W2053673554 @default.
- W4248285425 hasRelatedWork W2056368431 @default.
- W4248285425 hasRelatedWork W2403503433 @default.
- W4248285425 hasRelatedWork W4368374370 @default.
- W4248285425 hasRelatedWork W65482493 @default.
- W4248285425 isParatext "false" @default.
- W4248285425 isRetracted "false" @default.
- W4248285425 workType "dataset" @default.