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- W4248285426 endingPage "1062" @default.
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- W4248285426 abstract "Carbohydrates in the diet are digested in the small intestine to glucose, galactose, and fructose, and these sugars are then absorbed by enterocytes lining the upper third of the intestinal villi. Absorption occurs in two steps: first across the brush border membrane, and the second across the basolateral membrane. SGLT1 and GLUT5 are responsible for glucose, galactose, and fructose transport across the brush border membrane, and GLUT2 is thought to be responsible for glucose, galactose, and fructose across the basolateral membrane. Surprisingly, the molecular mechanism of sugar transport through these proteins is quite similar. The physiological importance of SGLT1 and GLUT2 in determining glucose absorption in vivo has been studied using OGTTs in Sglt1- and Glut2-null and wild-type mice. The results demonstrate that SGLT1 is important for fast glucose absorption, but the presence of GLUT2 is not so critical. SGLT1 plays an important role in water absorption. Given the success in the use of renal SGLT2 inhibitors in treating T2DM, focus has turned to developing SGLT1 inhibitors to control blood glucose levels in diabetes, and some success has been achieved in animal models." @default.
- W4248285426 created "2022-05-12" @default.
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- W4248285426 date "2018-01-01" @default.
- W4248285426 modified "2023-09-24" @default.
- W4248285426 title "Sugar Absorption" @default.
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- W4248285426 doi "https://doi.org/10.1016/b978-0-12-809954-4.00046-3" @default.
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