Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248289325> ?p ?o ?g. }
- W4248289325 endingPage "330" @default.
- W4248289325 startingPage "323" @default.
- W4248289325 abstract "Sequence variations in the Epstein-Barr virus (EBV) encoded latent membrane protein-1 (LMP-1) gene have been described in a Chinese nasopharyngeal carcinoma-derived isolate (CAO), and in viral isolates from various EBV-associated tumors. It has been suggested that these genetic changes, which include loss of a Xho I restriction site (position 169425) and a C-terminal 30-base pair (bp) deletion (position 168287-168256), define EBV genotypes associated with increased tumorigenicity or with disease among particular geographic populations. To determine the frequency of LMP-1 variations in European wild-type virus isolates, we sequenced the LMP1 promoter and gene in EBV from lymphoblastoid cell lines from healthy carriers and patients without EBV-associated disease. Sequence changes were often present, and defined at least four main groups of viral isolates, which we designate Groups A through D. The widespread prevalence of LMP-1 sequence variations, particularly the Xho I polymorphism and the 30-bp deletion, indicate that they cannot be used as simple markers for oncogenic viruses related to particular forms of EBV-associated tumor. Several of the structural changes detected occur, however, at sites where they may affect transcription, translation, or function of LMP-1. Future in vitro studies should aim to establish the functional importance of variations at these sites." @default.
- W4248289325 created "2022-05-12" @default.
- W4248289325 creator A5010553869 @default.
- W4248289325 creator A5020419651 @default.
- W4248289325 creator A5029319079 @default.
- W4248289325 creator A5052905013 @default.
- W4248289325 creator A5060163202 @default.
- W4248289325 creator A5068667098 @default.
- W4248289325 creator A5076941494 @default.
- W4248289325 creator A5083762748 @default.
- W4248289325 date "1997-07-01" @default.
- W4248289325 modified "2023-10-18" @default.
- W4248289325 title "Sequence Analysis of the Epstein-Barr Virus (EBV) Latent Membrane Protein-1 Gene and Promoter Region: Identification of Four Variants Among Wild-Type EBV Isolates" @default.
- W4248289325 cites W1517489176 @default.
- W4248289325 cites W1537501159 @default.
- W4248289325 cites W1567424359 @default.
- W4248289325 cites W1580392595 @default.
- W4248289325 cites W1763146100 @default.
- W4248289325 cites W1857962895 @default.
- W4248289325 cites W1966155521 @default.
- W4248289325 cites W1972992388 @default.
- W4248289325 cites W1977812239 @default.
- W4248289325 cites W1980464074 @default.
- W4248289325 cites W1996168666 @default.
- W4248289325 cites W2050129013 @default.
- W4248289325 cites W2057267741 @default.
- W4248289325 cites W2076559832 @default.
- W4248289325 cites W2079199354 @default.
- W4248289325 cites W2086932055 @default.
- W4248289325 cites W2101856856 @default.
- W4248289325 cites W2104923062 @default.
- W4248289325 cites W2110980603 @default.
- W4248289325 cites W2122886914 @default.
- W4248289325 cites W2133705142 @default.
- W4248289325 cites W2138811432 @default.
- W4248289325 cites W2143304040 @default.
- W4248289325 cites W2261588569 @default.
- W4248289325 cites W302046682 @default.
- W4248289325 cites W39844064 @default.
- W4248289325 cites W4249220136 @default.
- W4248289325 doi "https://doi.org/10.1182/blood.v90.1.323.323_323_330" @default.
- W4248289325 hasPublicationYear "1997" @default.
- W4248289325 type Work @default.
- W4248289325 citedByCount "23" @default.
- W4248289325 countsByYear W42482893252012 @default.
- W4248289325 countsByYear W42482893252013 @default.
- W4248289325 countsByYear W42482893252014 @default.
- W4248289325 countsByYear W42482893252015 @default.
- W4248289325 crossrefType "journal-article" @default.
- W4248289325 hasAuthorship W4248289325A5010553869 @default.
- W4248289325 hasAuthorship W4248289325A5020419651 @default.
- W4248289325 hasAuthorship W4248289325A5029319079 @default.
- W4248289325 hasAuthorship W4248289325A5052905013 @default.
- W4248289325 hasAuthorship W4248289325A5060163202 @default.
- W4248289325 hasAuthorship W4248289325A5068667098 @default.
- W4248289325 hasAuthorship W4248289325A5076941494 @default.
- W4248289325 hasAuthorship W4248289325A5083762748 @default.
- W4248289325 hasBestOaLocation W42482893251 @default.
- W4248289325 hasConcept C101762097 @default.
- W4248289325 hasConcept C104317684 @default.
- W4248289325 hasConcept C126322002 @default.
- W4248289325 hasConcept C135763542 @default.
- W4248289325 hasConcept C150194340 @default.
- W4248289325 hasConcept C159047783 @default.
- W4248289325 hasConcept C2522874641 @default.
- W4248289325 hasConcept C2776409557 @default.
- W4248289325 hasConcept C2778847070 @default.
- W4248289325 hasConcept C2778997737 @default.
- W4248289325 hasConcept C2780727368 @default.
- W4248289325 hasConcept C2781375147 @default.
- W4248289325 hasConcept C509974204 @default.
- W4248289325 hasConcept C54355233 @default.
- W4248289325 hasConcept C61053724 @default.
- W4248289325 hasConcept C71924100 @default.
- W4248289325 hasConcept C86803240 @default.
- W4248289325 hasConceptScore W4248289325C101762097 @default.
- W4248289325 hasConceptScore W4248289325C104317684 @default.
- W4248289325 hasConceptScore W4248289325C126322002 @default.
- W4248289325 hasConceptScore W4248289325C135763542 @default.
- W4248289325 hasConceptScore W4248289325C150194340 @default.
- W4248289325 hasConceptScore W4248289325C159047783 @default.
- W4248289325 hasConceptScore W4248289325C2522874641 @default.
- W4248289325 hasConceptScore W4248289325C2776409557 @default.
- W4248289325 hasConceptScore W4248289325C2778847070 @default.
- W4248289325 hasConceptScore W4248289325C2778997737 @default.
- W4248289325 hasConceptScore W4248289325C2780727368 @default.
- W4248289325 hasConceptScore W4248289325C2781375147 @default.
- W4248289325 hasConceptScore W4248289325C509974204 @default.
- W4248289325 hasConceptScore W4248289325C54355233 @default.
- W4248289325 hasConceptScore W4248289325C61053724 @default.
- W4248289325 hasConceptScore W4248289325C71924100 @default.
- W4248289325 hasConceptScore W4248289325C86803240 @default.
- W4248289325 hasIssue "1" @default.
- W4248289325 hasLocation W42482893251 @default.
- W4248289325 hasOpenAccess W4248289325 @default.
- W4248289325 hasPrimaryLocation W42482893251 @default.
- W4248289325 hasRelatedWork W1981201050 @default.
- W4248289325 hasRelatedWork W1989757416 @default.