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- W42483223 abstract "Because (Ca)i is postulated to influence BP, we assessed the hypotensive effects of a dairy-rich diet and whether the effects differed according to changes in (Ca)i. Using a randomized, 3-period, cross-over design, 23 stage 1 hypertensive adults were fed 3 experimental diets (5 wk each); high dairy, high fruits and vegetables diet (D-F&V; 30% fat, 7% saturated fat (SFA), 3.4 servings/d dairy), a low dairy, high fruits and vegetables diet (F&V; 30% fat, 7% SFA, 0.4 servings/d dairy), and an average Western diet (AWD; 36% fat, 15% SFA, 0.4 servings/d dairy). Systolic (SBP) and diastolic (DBP) blood pressure, calcitriol, and erythrocyte (Ca)i were determined. SBP and DBP were significantly reduced by ~2 mm Hg following both D-F&V and F&V diets vs. AWD (P<0.05 for each). The D-F&V diet significantly lowered calcitriol and (Ca)i vs. the two dairy-poor diets (P<0.01 for each). The reduction in (Ca)i correlated with the fall in DBP (r=0.55, P<0.03). Subjects who responded to the D-F&V diet by significantly reducing (Ca)i exhibited significantly greater drops in DBP on the D-F&V (−14 ± 3.4 mm Hg) vs. the F&V (−10 ± 3.4 mm Hg) and AWD diets (−8 ± 3.4 mm Hg; diet x group interaction, P<0.02). The results suggest that (Ca)i is responsive to diet and that a dairy-rich diet produces an ideal intracellular environment, which may result in improved BP. Funding: Dairy Management Inc., GCRC of Penn State University NIH M01 RR10732" @default.
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- W42483223 date "2007-01-01" @default.
- W42483223 modified "2023-09-26" @default.
- W42483223 title "Effects of a dairy‐rich diet on blood pressure (BP): moderating effects of intracellular calcium [(Ca)i ] status" @default.
- W42483223 doi "https://doi.org/10.1096/fasebj.21.6.a1061" @default.
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