Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248374705> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4248374705 abstract "Abstract Background Mounting evidence suggests that solid tumors display the features of collective invasion, however, the molecular mechanisms are far from clear. This study aims to verify the role and the underlying mechanisms of CD147 in collective invasion in hepatocellular carcinoma. Methods Immunostaining was used to analyze human hepatocellular carcinoma specimens and three-dimensional cultures. Three-dimensional invasion model was established to mimic in vivo invasion. RNA-sequencing was used to identify downstream effectors. Results Human hepatocellular carcinoma undergone collective invasion and CD147 was observed to be upregulated at the invasive front of tumor cell groups. CD147 was demonstrated to promote collective invasion using the modified three-dimensional invasion model, which recapitulated the main features of collective invasion. Through transcriptome analysis and enzyme activity assay, we found that CD147 enhanced cathepsin B expression and activation. Upregulated cathepsin B in hepatocellular carcinoma cells facilitated migration and invasion, which mediated CD147-induced invasive phenotype in hepatocellular carcinoma. In terms of mechanism, we found that CD147 promoted cathepsin B transcription by activating β-catenin signaling as a result of reduced GSK-3β expression. Furthermore, we found that elevated expression of CD147 as well as cathepsin B were correlated with poor prognosis in patients with hepatocellular carcinoma. Conclusions CD147 promotes hepatocellular carcinoma cells collective invasion via upregulating cathepsin B expression and targeting CD147 would be valuable for the development of novel therapeutic modalities against invasion and metastasis of cancer." @default.
- W4248374705 created "2022-05-12" @default.
- W4248374705 creator A5001330715 @default.
- W4248374705 creator A5003799076 @default.
- W4248374705 creator A5010696053 @default.
- W4248374705 creator A5011443609 @default.
- W4248374705 creator A5018051539 @default.
- W4248374705 creator A5027880821 @default.
- W4248374705 creator A5035195373 @default.
- W4248374705 creator A5060160694 @default.
- W4248374705 creator A5070334057 @default.
- W4248374705 creator A5072861069 @default.
- W4248374705 date "2020-07-20" @default.
- W4248374705 modified "2023-10-04" @default.
- W4248374705 title "CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma" @default.
- W4248374705 doi "https://doi.org/10.21203/rs.3.rs-28652/v2" @default.
- W4248374705 hasPublicationYear "2020" @default.
- W4248374705 type Work @default.
- W4248374705 citedByCount "0" @default.
- W4248374705 crossrefType "posted-content" @default.
- W4248374705 hasAuthorship W4248374705A5001330715 @default.
- W4248374705 hasAuthorship W4248374705A5003799076 @default.
- W4248374705 hasAuthorship W4248374705A5010696053 @default.
- W4248374705 hasAuthorship W4248374705A5011443609 @default.
- W4248374705 hasAuthorship W4248374705A5018051539 @default.
- W4248374705 hasAuthorship W4248374705A5027880821 @default.
- W4248374705 hasAuthorship W4248374705A5035195373 @default.
- W4248374705 hasAuthorship W4248374705A5060160694 @default.
- W4248374705 hasAuthorship W4248374705A5070334057 @default.
- W4248374705 hasAuthorship W4248374705A5072861069 @default.
- W4248374705 hasBestOaLocation W42483747051 @default.
- W4248374705 hasConcept C104317684 @default.
- W4248374705 hasConcept C121608353 @default.
- W4248374705 hasConcept C127561419 @default.
- W4248374705 hasConcept C142724271 @default.
- W4248374705 hasConcept C181199279 @default.
- W4248374705 hasConcept C203014093 @default.
- W4248374705 hasConcept C204232928 @default.
- W4248374705 hasConcept C2778019345 @default.
- W4248374705 hasConcept C2779013556 @default.
- W4248374705 hasConcept C28021979 @default.
- W4248374705 hasConcept C4224716 @default.
- W4248374705 hasConcept C502942594 @default.
- W4248374705 hasConcept C54355233 @default.
- W4248374705 hasConcept C55493867 @default.
- W4248374705 hasConcept C71924100 @default.
- W4248374705 hasConcept C86803240 @default.
- W4248374705 hasConceptScore W4248374705C104317684 @default.
- W4248374705 hasConceptScore W4248374705C121608353 @default.
- W4248374705 hasConceptScore W4248374705C127561419 @default.
- W4248374705 hasConceptScore W4248374705C142724271 @default.
- W4248374705 hasConceptScore W4248374705C181199279 @default.
- W4248374705 hasConceptScore W4248374705C203014093 @default.
- W4248374705 hasConceptScore W4248374705C204232928 @default.
- W4248374705 hasConceptScore W4248374705C2778019345 @default.
- W4248374705 hasConceptScore W4248374705C2779013556 @default.
- W4248374705 hasConceptScore W4248374705C28021979 @default.
- W4248374705 hasConceptScore W4248374705C4224716 @default.
- W4248374705 hasConceptScore W4248374705C502942594 @default.
- W4248374705 hasConceptScore W4248374705C54355233 @default.
- W4248374705 hasConceptScore W4248374705C55493867 @default.
- W4248374705 hasConceptScore W4248374705C71924100 @default.
- W4248374705 hasConceptScore W4248374705C86803240 @default.
- W4248374705 hasLocation W42483747051 @default.
- W4248374705 hasLocation W42483747052 @default.
- W4248374705 hasLocation W42483747053 @default.
- W4248374705 hasOpenAccess W4248374705 @default.
- W4248374705 hasPrimaryLocation W42483747051 @default.
- W4248374705 hasRelatedWork W2054174996 @default.
- W4248374705 hasRelatedWork W2086968193 @default.
- W4248374705 hasRelatedWork W2801632896 @default.
- W4248374705 hasRelatedWork W2806814376 @default.
- W4248374705 hasRelatedWork W2979815966 @default.
- W4248374705 hasRelatedWork W3000433925 @default.
- W4248374705 hasRelatedWork W3021125337 @default.
- W4248374705 hasRelatedWork W3097440222 @default.
- W4248374705 hasRelatedWork W4292080754 @default.
- W4248374705 hasRelatedWork W4366998568 @default.
- W4248374705 isParatext "false" @default.
- W4248374705 isRetracted "false" @default.
- W4248374705 workType "article" @default.