Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248388052> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4248388052 endingPage "173" @default.
- W4248388052 startingPage "165" @default.
- W4248388052 abstract "Objective: In elderly patients the results of cardiac interventions are inferior to those in the young. A possible contributing factor is an age-related reduction in cellular energy transduction during the intervention which may induce aerobic or ischemic stress. To investigate whether coenzyme Q10 (CoQ10) improves the response to aerobic stress, functional recoveries of senescent and young rat hearts after rapid pacing were compared with or without CoQ10. Methods: Young (4.8±0.1 months) and senescent (35.3±0.2 months) rats were given daily intraperitoneal injections of CoQ10 (4 mg/kg) or vehicle for 6 weeks. Their isolated hearts were rapidly paced at 510 beats per minute for 120 min to induce aerobic stress without ischemia. Results: In senescent hearts pre-pacing cardiac work was 74% and oxygen consumption (MVO2) 66% of that in young hearts. CoQ10 treatment abolished these differences. After pacing, the untreated senescent hearts, compared to young, showed reduced recovery of pre-pacing work, (16.8±4.3 vs. 44.5±7.4%; P<0.01). CoQ10 treatment in senescent hearts improved recovery of work, (48.1±4.1 vs. 16.8±4.3%; P<0.0001) and MVO2 (82.1±2.8 vs. 61.3±4.0%; P<0.01) in treated versus untreated hearts respectively. Post-pacing levels of these parameters in CoQ10 treated senescent hearts were as high as in young hearts. Conclusions: (1) Senescent rat hearts have reduced baseline function and reduced tolerance to aerobic stress compared to young hearts. (2) Pre-treatment with CoQ10 improves baseline function of the senescent myocardium and its tolerance to aerobic stress." @default.
- W4248388052 created "2022-05-12" @default.
- W4248388052 creator A5014170799 @default.
- W4248388052 creator A5050945409 @default.
- W4248388052 creator A5059230075 @default.
- W4248388052 creator A5080889022 @default.
- W4248388052 date "1998-10-01" @default.
- W4248388052 modified "2023-09-27" @default.
- W4248388052 title "Coenzyme Q10 treatment improves the tolerance of the senescent myocardium to pacing stress in the rat" @default.
- W4248388052 cites W1497671643 @default.
- W4248388052 cites W1965270206 @default.
- W4248388052 cites W1966759550 @default.
- W4248388052 cites W1974396693 @default.
- W4248388052 cites W1980500760 @default.
- W4248388052 cites W1989574042 @default.
- W4248388052 cites W1989912623 @default.
- W4248388052 cites W1997934822 @default.
- W4248388052 cites W2003471941 @default.
- W4248388052 cites W2018074348 @default.
- W4248388052 cites W2023677185 @default.
- W4248388052 cites W2024268789 @default.
- W4248388052 cites W2028873508 @default.
- W4248388052 cites W2035144626 @default.
- W4248388052 cites W2043737958 @default.
- W4248388052 cites W2043823315 @default.
- W4248388052 cites W2047016835 @default.
- W4248388052 cites W2049987769 @default.
- W4248388052 cites W2070409655 @default.
- W4248388052 cites W2075685752 @default.
- W4248388052 cites W2080285113 @default.
- W4248388052 cites W2094978335 @default.
- W4248388052 cites W2147697315 @default.
- W4248388052 cites W2162107616 @default.
- W4248388052 cites W2167308940 @default.
- W4248388052 cites W2321796526 @default.
- W4248388052 cites W2411562421 @default.
- W4248388052 cites W2418202169 @default.
- W4248388052 cites W2462964851 @default.
- W4248388052 doi "https://doi.org/10.1016/s0008-6363(98)00132-1" @default.
- W4248388052 hasPublicationYear "1998" @default.
- W4248388052 type Work @default.
- W4248388052 citedByCount "23" @default.
- W4248388052 countsByYear W42483880522014 @default.
- W4248388052 countsByYear W42483880522017 @default.
- W4248388052 crossrefType "journal-article" @default.
- W4248388052 hasAuthorship W4248388052A5014170799 @default.
- W4248388052 hasAuthorship W4248388052A5050945409 @default.
- W4248388052 hasAuthorship W4248388052A5059230075 @default.
- W4248388052 hasAuthorship W4248388052A5080889022 @default.
- W4248388052 hasBestOaLocation W42483880521 @default.
- W4248388052 hasConcept C111566952 @default.
- W4248388052 hasConcept C126322002 @default.
- W4248388052 hasConcept C134018914 @default.
- W4248388052 hasConcept C164705383 @default.
- W4248388052 hasConcept C2776151105 @default.
- W4248388052 hasConcept C2778198053 @default.
- W4248388052 hasConcept C2779384338 @default.
- W4248388052 hasConcept C541997718 @default.
- W4248388052 hasConcept C71924100 @default.
- W4248388052 hasConceptScore W4248388052C111566952 @default.
- W4248388052 hasConceptScore W4248388052C126322002 @default.
- W4248388052 hasConceptScore W4248388052C134018914 @default.
- W4248388052 hasConceptScore W4248388052C164705383 @default.
- W4248388052 hasConceptScore W4248388052C2776151105 @default.
- W4248388052 hasConceptScore W4248388052C2778198053 @default.
- W4248388052 hasConceptScore W4248388052C2779384338 @default.
- W4248388052 hasConceptScore W4248388052C541997718 @default.
- W4248388052 hasConceptScore W4248388052C71924100 @default.
- W4248388052 hasIssue "1" @default.
- W4248388052 hasLocation W42483880521 @default.
- W4248388052 hasOpenAccess W4248388052 @default.
- W4248388052 hasPrimaryLocation W42483880521 @default.
- W4248388052 hasRelatedWork W2063793917 @default.
- W4248388052 hasRelatedWork W2363366439 @default.
- W4248388052 hasRelatedWork W2375703560 @default.
- W4248388052 hasRelatedWork W2386991455 @default.
- W4248388052 hasRelatedWork W2388694570 @default.
- W4248388052 hasRelatedWork W2390396046 @default.
- W4248388052 hasRelatedWork W2748952813 @default.
- W4248388052 hasRelatedWork W2915561147 @default.
- W4248388052 hasRelatedWork W3031164927 @default.
- W4248388052 hasRelatedWork W3160140598 @default.
- W4248388052 hasVolume "40" @default.
- W4248388052 isParatext "false" @default.
- W4248388052 isRetracted "false" @default.
- W4248388052 workType "article" @default.