Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248412843> ?p ?o ?g. }
- W4248412843 endingPage "98" @default.
- W4248412843 startingPage "71" @default.
- W4248412843 abstract "Ribonucleotide reductases provide the building blocks for DNA replication in all living cells. Three different classes of enzymes use protein free radicals to activate the substrate. Aerobic class I enzymes generate a tyrosyl radical with an iron-oxygen center and dioxygen, class II enzymes employ adenosylcobalamin, and the anaerobic class III enzymes generate a glycyl radical from S-adenosylmethionine and an iron-sulfur cluster. The X-ray structure of the class I Escherichia coli enzyme, including forms that bind substrate and allosteric effectors, confirms previous models of catalytic and allosteric mechanisms. This structure suggests considerable mobility of the protein during catalysis and, together with experiments involving site-directed mutants, suggests a mechanism for radical transfer from one subunit to the other. Despite large differences between the classes, common catalytic and allosteric mechanisms, as well as retention of critical residues in the protein sequence, suggest a similar tertiary structure and a common origin during evolution. One puzzling aspect is that some organisms contain the genes for several different reductases." @default.
- W4248412843 created "2022-05-12" @default.
- W4248412843 creator A5003486360 @default.
- W4248412843 creator A5068554777 @default.
- W4248412843 date "1998-06-01" @default.
- W4248412843 modified "2023-10-10" @default.
- W4248412843 title "RIBONUCLEOTIDE REDUCTASES" @default.
- W4248412843 cites W1482410919 @default.
- W4248412843 cites W148684060 @default.
- W4248412843 cites W1495408999 @default.
- W4248412843 cites W1502915399 @default.
- W4248412843 cites W1503716838 @default.
- W4248412843 cites W1505015949 @default.
- W4248412843 cites W1506430822 @default.
- W4248412843 cites W1521414998 @default.
- W4248412843 cites W1536062643 @default.
- W4248412843 cites W1538207008 @default.
- W4248412843 cites W1555725382 @default.
- W4248412843 cites W1558073946 @default.
- W4248412843 cites W1564378669 @default.
- W4248412843 cites W1564559265 @default.
- W4248412843 cites W1568700182 @default.
- W4248412843 cites W1572756764 @default.
- W4248412843 cites W1577909961 @default.
- W4248412843 cites W1582588152 @default.
- W4248412843 cites W1589868601 @default.
- W4248412843 cites W1590696074 @default.
- W4248412843 cites W1590995017 @default.
- W4248412843 cites W1593007806 @default.
- W4248412843 cites W1594338269 @default.
- W4248412843 cites W1598595895 @default.
- W4248412843 cites W1600179333 @default.
- W4248412843 cites W1605632595 @default.
- W4248412843 cites W1625888066 @default.
- W4248412843 cites W1634487747 @default.
- W4248412843 cites W1636387388 @default.
- W4248412843 cites W1640573482 @default.
- W4248412843 cites W1653081612 @default.
- W4248412843 cites W1673365275 @default.
- W4248412843 cites W1689364519 @default.
- W4248412843 cites W1690216835 @default.
- W4248412843 cites W1713951784 @default.
- W4248412843 cites W1752397324 @default.
- W4248412843 cites W1767121311 @default.
- W4248412843 cites W1783543920 @default.
- W4248412843 cites W178922452 @default.
- W4248412843 cites W1892791637 @default.
- W4248412843 cites W193888849 @default.
- W4248412843 cites W1946097499 @default.
- W4248412843 cites W1964007399 @default.
- W4248412843 cites W1964824966 @default.
- W4248412843 cites W1965429549 @default.
- W4248412843 cites W1965434130 @default.
- W4248412843 cites W1965635445 @default.
- W4248412843 cites W1967700370 @default.
- W4248412843 cites W1967830103 @default.
- W4248412843 cites W1968118415 @default.
- W4248412843 cites W1969617308 @default.
- W4248412843 cites W1971403296 @default.
- W4248412843 cites W1972122823 @default.
- W4248412843 cites W1972339373 @default.
- W4248412843 cites W1977560251 @default.
- W4248412843 cites W1979563025 @default.
- W4248412843 cites W1980665630 @default.
- W4248412843 cites W1982410689 @default.
- W4248412843 cites W1982423805 @default.
- W4248412843 cites W1983901754 @default.
- W4248412843 cites W1984605430 @default.
- W4248412843 cites W1985641334 @default.
- W4248412843 cites W1988761948 @default.
- W4248412843 cites W1993398625 @default.
- W4248412843 cites W1999928429 @default.
- W4248412843 cites W2000884916 @default.
- W4248412843 cites W2005263150 @default.
- W4248412843 cites W2008854562 @default.
- W4248412843 cites W2009416343 @default.
- W4248412843 cites W2010105734 @default.
- W4248412843 cites W2011442761 @default.
- W4248412843 cites W2012945970 @default.
- W4248412843 cites W2019684813 @default.
- W4248412843 cites W2021313959 @default.
- W4248412843 cites W2021585625 @default.
- W4248412843 cites W2023420297 @default.
- W4248412843 cites W2024610281 @default.
- W4248412843 cites W2027382867 @default.
- W4248412843 cites W2029473646 @default.
- W4248412843 cites W2032152464 @default.
- W4248412843 cites W2034301317 @default.
- W4248412843 cites W2035067626 @default.
- W4248412843 cites W2037313086 @default.
- W4248412843 cites W2037834117 @default.
- W4248412843 cites W2041652393 @default.
- W4248412843 cites W2045601762 @default.
- W4248412843 cites W2047167565 @default.
- W4248412843 cites W2047747423 @default.
- W4248412843 cites W2049749669 @default.
- W4248412843 cites W2049899679 @default.
- W4248412843 cites W2050088367 @default.