FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248429043> ?p ?o ?g. }

• W4248429043 endingPage "481" @default.
• W4248429043 startingPage "474" @default.
• W4248429043 abstract "Objective To test whether the menopause entails any changes in the myeloperoxidase activity of neutrophil granulocytes. The effects of hormone replacement therapy on myeloperoxidase activity and related changes in free radical production were also investigated. Design Laboratory investigation of the effect of oestrogen on intracellular myeloperoxidase activity and release from human neutrophil granulocytes. Analysis of related changes in superoxide anion generation. Setting 2nd Department of Medicine and 1st Department of Obstetrics and Gynaecology, Semmelweis University, Budapest. Samples Intracellular myeloperoxidase activity (mean peroxidase index) was measured automatically in blood samples obtained for general laboratory work-up from 135 randomly selected patients in our department. Blood samples from 11 postmenopausal women were analysed before and during hormone replacement therapy. Blood samples from 20 healthy volunteers were obtained and neutrophil granulocytes separated for in vitro measurement of superoxide anion production after adding myeloperoxidase to the incubation media. Methods The mean peroxidase index was measured using a Technicon H-3 instrument. myeloperoxidase release from neutrophils was quantified by ELISA technique. Superoxide production of isolated neutrophil granulocytes was measured by photometry. Main outcome measures Intracellular activity of myeloperoxidase, concentration of myeloperoxidase-protein in supernatant of neutrophils, release of superoxide anion from neutrophil granulocytes. Results 1. Intracellular myeloperoxidase activity in neutrophils was lower in postmenopausal women, than in females with regular cycles (-1.84 ±3.06 versus 1.59 ±3.55, P<0,001). 2. In postmenopausal women intracellular myeloperoxidase activity and myeloperoxidase release increased during hormone replacement therapy (-5.54 ±6.63 versus -0.2 ±6.05; P<0.001 and 52.74 mU/ml ±25.73 versus 251.4 ±234.1 mU/ml; P<0.05). 3. Adding myeloperoxidase to neutrophil granulocyte suspensions, the production of superoxide anion fell (e.g. adding 280 ng/ml myeloperoxidase: 77.9 ±14.04 % of control production, P<0.001). Conclusion Hormone replacement restores the reduced myeloperoxidase activity in menopausal women. Adding myeloperoxidase to neutrophil granulocytes, the production of free radicals decreases." @default.
• W4248429043 created "2022-05-12" @default.
• W4248429043 creator A5018506651 @default.
• W4248429043 creator A5038073753 @default.
• W4248429043 creator A5041876762 @default.
• W4248429043 creator A5042227378 @default.
• W4248429043 creator A5048982379 @default.
• W4248429043 creator A5062808329 @default.
• W4248429043 creator A5081591659 @default.
• W4248429043 creator A5086011600 @default.
• W4248429043 date "2001-05-01" @default.
• W4248429043 modified "2023-10-17" @default.
• W4248429043 title "Induced myeloperoxidase activity and related superoxide inhibition during hormone replacement therapy" @default.
• W4248429043 cites W1576614076 @default.
• W4248429043 cites W1586099293 @default.
• W4248429043 cites W1587377234 @default.
• W4248429043 cites W1644991946 @default.
• W4248429043 cites W1926238032 @default.
• W4248429043 cites W1964483540 @default.
• W4248429043 cites W1965340455 @default.
• W4248429043 cites W1970459082 @default.
• W4248429043 cites W1971805299 @default.
• W4248429043 cites W1971844607 @default.
• W4248429043 cites W1974580748 @default.
• W4248429043 cites W1976094641 @default.
• W4248429043 cites W1986703071 @default.
• W4248429043 cites W1998267683 @default.
• W4248429043 cites W2011670951 @default.
• W4248429043 cites W2031470225 @default.
• W4248429043 cites W2035961359 @default.
• W4248429043 cites W2041789552 @default.
• W4248429043 cites W2041937485 @default.
• W4248429043 cites W2048617769 @default.
• W4248429043 cites W2052562838 @default.
• W4248429043 cites W2061339585 @default.
• W4248429043 cites W2065318045 @default.
• W4248429043 cites W2066438974 @default.
• W4248429043 cites W2079735654 @default.
• W4248429043 cites W2082218696 @default.
• W4248429043 cites W2106519758 @default.
• W4248429043 cites W2108834458 @default.
• W4248429043 cites W2166432285 @default.
• W4248429043 cites W2174934515 @default.
• W4248429043 cites W2324099646 @default.
• W4248429043 cites W2324910920 @default.
• W4248429043 cites W4235141812 @default.
• W4248429043 cites W55232853 @default.
• W4248429043 doi "https://doi.org/10.1016/s0306-5456(00)00108-x" @default.
• W4248429043 hasPublicationYear "2001" @default.
• W4248429043 type Work @default.
• W4248429043 citedByCount "6" @default.
• W4248429043 countsByYear W42484290432017 @default.
• W4248429043 countsByYear W42484290432020 @default.
• W4248429043 crossrefType "journal-article" @default.
• W4248429043 hasAuthorship W4248429043A5018506651 @default.
• W4248429043 hasAuthorship W4248429043A5038073753 @default.
• W4248429043 hasAuthorship W4248429043A5041876762 @default.
• W4248429043 hasAuthorship W4248429043A5042227378 @default.
• W4248429043 hasAuthorship W4248429043A5048982379 @default.
• W4248429043 hasAuthorship W4248429043A5062808329 @default.
• W4248429043 hasAuthorship W4248429043A5081591659 @default.
• W4248429043 hasAuthorship W4248429043A5086011600 @default.
• W4248429043 hasConcept C126322002 @default.
• W4248429043 hasConcept C134018914 @default.
• W4248429043 hasConcept C162008176 @default.
• W4248429043 hasConcept C16685009 @default.
• W4248429043 hasConcept C181199279 @default.
• W4248429043 hasConcept C185592680 @default.
• W4248429043 hasConcept C203014093 @default.
• W4248429043 hasConcept C203565725 @default.
• W4248429043 hasConcept C2776914184 @default.
• W4248429043 hasConcept C2780795997 @default.
• W4248429043 hasConcept C55493867 @default.
• W4248429043 hasConcept C71924100 @default.
• W4248429043 hasConcept C79879829 @default.
• W4248429043 hasConceptScore W4248429043C126322002 @default.
• W4248429043 hasConceptScore W4248429043C134018914 @default.
• W4248429043 hasConceptScore W4248429043C162008176 @default.
• W4248429043 hasConceptScore W4248429043C16685009 @default.
• W4248429043 hasConceptScore W4248429043C181199279 @default.
• W4248429043 hasConceptScore W4248429043C185592680 @default.
• W4248429043 hasConceptScore W4248429043C203014093 @default.
• W4248429043 hasConceptScore W4248429043C203565725 @default.
• W4248429043 hasConceptScore W4248429043C2776914184 @default.
• W4248429043 hasConceptScore W4248429043C2780795997 @default.
• W4248429043 hasConceptScore W4248429043C55493867 @default.
• W4248429043 hasConceptScore W4248429043C71924100 @default.
• W4248429043 hasConceptScore W4248429043C79879829 @default.
• W4248429043 hasIssue "5" @default.
• W4248429043 hasLocation W42484290431 @default.
• W4248429043 hasOpenAccess W4248429043 @default.
• W4248429043 hasPrimaryLocation W42484290431 @default.
• W4248429043 hasRelatedWork W131281969 @default.
• W4248429043 hasRelatedWork W1986176507 @default.
• W4248429043 hasRelatedWork W2017749390 @default.
• W4248429043 hasRelatedWork W2037157726 @default.
• W4248429043 hasRelatedWork W2051208451 @default.
• W4248429043 hasRelatedWork W2136913138 @default.

• next